Parkinson's disease

P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity
Alexia F. Kalogeropulou, Jing Zhao, Marc F. Bolliger, Anna Memou, Shreya Narasimha, Tyler P. Molitor, William H. Wilson, Hardy J. Rideout, R. Jeremy Nichols

Biochemical Journal Apr 2018, 475 (7) 1271-1293; DOI: 10.1042/BCJ20170699
Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease
Patrick A. Eyers

Biochemical Journal Jan 2018, 475 (1) 185-189; DOI: 10.1042/BCJ20170870
Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils
Ying Fan, Andrew J.M. Howden, Adil R. Sarhan, Pawel Lis, Genta Ito, Terina N. Martinez, Kathrin Brockmann, Thomas Gasser, Dario R. Alessi, Esther M. Sammler

Biochemical Journal Jan 2018, 475 (1) 23-44; DOI: 10.1042/BCJ20170803
Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase
Pawel Lis, Sophie Burel, Martin Steger, Matthias Mann, Fiona Brown, Federico Diez, Francesca Tonelli, Janice L. Holton, Philip Winglok Ho, Shu-Leong Ho, Meng-Yun Chou, Nicole K. Polinski, Terina N. Martinez, Paul Davies, Dario R. Alessi

Biochemical Journal Jan 2018, 475 (1) 1-22; DOI: 10.1042/BCJ20170802
Activation mechanisms of the E3 ubiquitin ligase parkin
Nikhil Panicker, Valina L. Dawson, Ted M. Dawson

Biochemical Journal Sep 2017, 474 (18) 3075-3086; DOI: 10.1042/BCJ20170476
The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2
Iakov N. Rudenko, Alice Kaganovich, Rebekah G. Langston, Aleksandra Beilina, Kelechi Ndukwe, Ravindran Kumaran, Allissa A. Dillman, Ruth Chia, Mark R. Cookson

Biochemical Journal May 2017, 474 (9) 1547-1558; DOI: 10.1042/BCJ20160909
Ubiquitin and Parkinson's disease through the looking glass of genetics
Helen Walden, Miratul M.K. Muqit

Biochemical Journal May 2017, 474 (9) 1439-1451; DOI: 10.1042/BCJ20160498
Structural interface between LRRK2 and 14-3-3 protein
Loes M. Stevers, Rens M.J.M. de Vries, Richard G. Doveston, Lech-Gustav Milroy, Luc Brunsveld, Christian Ottmann

Biochemical Journal Apr 2017, 474 (7) 1273-1287; DOI: 10.1042/BCJ20161078
‘Up with the LRRK’: a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement
Patrick A. Eyers

Biochemical Journal Sep 2016, 473 (18) 2757-2762; DOI: 10.1042/BCJ20160671C
Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors
Genta Ito, Kristina Katsemonova, Francesca Tonelli, Pawel Lis, Marco A.S. Baptista, Natalia Shpiro, Graham Duddy, Steve Wilson, Philip Wing-Lok Ho, Shu-Leong Ho, Alastair D. Reith, Dario R. Alessi

Biochemical Journal Sep 2016, 473 (17) 2671-2685; DOI: 10.1042/BCJ20160557

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