Parkinson's disease

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors
Genta Ito, Kristina Katsemonova, Francesca Tonelli, Pawel Lis, Marco A.S. Baptista, Natalia Shpiro, Graham Duddy, Steve Wilson, Philip Wing-Lok Ho, Shu-Leong Ho, Alastair D. Reith, Dario R. Alessi

Biochemical Journal Sep 2016, 473 (17) 2671-2685; DOI: 10.1042/BCJ20160557
LRRK2 dephosphorylation increases its ubiquitination
Jing Zhao, Tyler P. Molitor, J. William Langston, R. Jeremy Nichols

Biochemical Journal Jul 2015, 469 (1) 107-120; DOI: 10.1042/BJ20141305
DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating pink1
Raquel Requejo-Aguilar, Irene Lopez-Fabuel, Daniel Jimenez-Blasco, Emilio Fernandez, Angeles Almeida, Juan P. Bolaños

Biochemical Journal Apr 2015, 467 (2) 303-310; DOI: 10.1042/BJ20141025
Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies
Paul Davies, Kelly M. Hinkle, Nour N. Sukar, Bryan Sepulveda, Roxana Mesias, Geidy Serrano, Dario R. Alessi, Thomas G. Beach, Deanna L. Benson, Charles L. White, Rita M. Cowell, Sonal S. Das, Andrew B. West, Heather L. Melrose

Biochemical Journal Jul 2013, 453 (1) 101-113; DOI: 10.1042/BJ20121742
Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure
María Soledad Celej, Rabia Sarroukh, Erik Goormaghtigh, Gerardo D. Fidelio, Jean-Marie Ruysschaert, Vincent Raussens

Biochemical Journal May 2012, 443 (3) 719-726; DOI: 10.1042/BJ20111924
Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form
Genta Ito, Takeshi Iwatsubo

Biochemical Journal Feb 2012, 441 (3) 987-998; DOI: 10.1042/BJ20111215
Aggregation of amyloids in a cellular context: modelling and experiment
Ran Friedman

Biochemical Journal Sep 2011, 438 (3) 415-426; DOI: 10.1042/BJ20110369
The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors
Richard B. Parsons, Shylesh Aravindan, Anusha Kadampeswaran, Emily A. Evans, Kanwaljeet K. Sandhu, Elizabeth R. Levy, Martin G. Thomas, Brian M. Austen, David B. Ramsden

Biochemical Journal May 2011, 436 (1) 145-155; DOI: 10.1042/BJ20101685
14-3-3 proteins are promising LRRK2 interactors
Iakov N. Rudenko, Mark R. Cookson

Biochemical Journal Sep 2010, 430 (3) e5-e6; DOI: 10.1042/BJ20101200
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
R. Jeremy Nichols, Nicolas Dzamko, Nicholas A. Morrice, David G. Campbell, Maria Deak, Alban Ordureau, Thomas Macartney, Youren Tong, Jie Shen, Alan R. Prescott, Dario R. Alessi

Biochemical Journal Sep 2010, 430 (3) 393-404; DOI: 10.1042/BJ20100483

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