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Parkinson's disease

  • Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors
    Genta Ito, Kristina Katsemonova, Francesca Tonelli, Pawel Lis, Marco A.S. Baptista, Natalia Shpiro, Graham Duddy, Steve Wilson, Philip Wing-Lok Ho, Shu-Leong Ho, Alastair D. Reith, Dario R. Alessi
    Biochemical Journal Sep 2016, 473 (17) 2671-2685; DOI: 10.1042/BCJ20160557
  • LRRK2 dephosphorylation increases its ubiquitination
    Jing Zhao, Tyler P. Molitor, J. William Langston, R. Jeremy Nichols
    Biochemical Journal Jul 2015, 469 (1) 107-120; DOI: 10.1042/BJ20141305
  • DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating pink1
    Raquel Requejo-Aguilar, Irene Lopez-Fabuel, Daniel Jimenez-Blasco, Emilio Fernandez, Angeles Almeida, Juan P. Bolaños
    Biochemical Journal Apr 2015, 467 (2) 303-310; DOI: 10.1042/BJ20141025
  • Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies
    Paul Davies, Kelly M. Hinkle, Nour N. Sukar, Bryan Sepulveda, Roxana Mesias, Geidy Serrano, Dario R. Alessi, Thomas G. Beach, Deanna L. Benson, Charles L. White, Rita M. Cowell, Sonal S. Das, Andrew B. West, Heather L. Melrose
    Biochemical Journal Jul 2013, 453 (1) 101-113; DOI: 10.1042/BJ20121742
  • Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure
    María Soledad Celej, Rabia Sarroukh, Erik Goormaghtigh, Gerardo D. Fidelio, Jean-Marie Ruysschaert, Vincent Raussens
    Biochemical Journal May 2012, 443 (3) 719-726; DOI: 10.1042/BJ20111924
  • Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form
    Genta Ito, Takeshi Iwatsubo
    Biochemical Journal Feb 2012, 441 (3) 987-998; DOI: 10.1042/BJ20111215
  • Aggregation of amyloids in a cellular context: modelling and experiment
    Ran Friedman
    Biochemical Journal Sep 2011, 438 (3) 415-426; DOI: 10.1042/BJ20110369
  • The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors
    Richard B. Parsons, Shylesh Aravindan, Anusha Kadampeswaran, Emily A. Evans, Kanwaljeet K. Sandhu, Elizabeth R. Levy, Martin G. Thomas, Brian M. Austen, David B. Ramsden
    Biochemical Journal May 2011, 436 (1) 145-155; DOI: 10.1042/BJ20101685
  • 14-3-3 proteins are promising LRRK2 interactors
    Iakov N. Rudenko, Mark R. Cookson
    Biochemical Journal Sep 2010, 430 (3) e5-e6; DOI: 10.1042/BJ20101200
  • 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
    R. Jeremy Nichols, Nicolas Dzamko, Nicholas A. Morrice, David G. Campbell, Maria Deak, Alban Ordureau, Thomas Macartney, Youren Tong, Jie Shen, Alan R. Prescott, Dario R. Alessi
    Biochemical Journal Sep 2010, 430 (3) 393-404; DOI: 10.1042/BJ20100483

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