Parkinson's disease

Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes
Emmanouela Leandrou, Eliana Markidi, Anna Memou, Katerina Melachroinou, Elisa Greggio, Hardy J. Rideout

Biochemical Journal Feb 2019, 476 (3) 559-579; DOI: 10.1042/BCJ20180589
Validation of anti-glucocerebrosidase antibodies for western blot analysis on protein lysates of murine and human cells
Wenduo Qi, Brad A. Davidson, Matthew Nguyen, Taylor Lindstrom, Richard J. Grey, Robert Burnett, Elma Aflaki, Ellen Sidransky, Wendy Westbroek

Biochemical Journal Jan 2019, 476 (2) 261-274; DOI: 10.1042/BCJ20180708
P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity
Alexia F. Kalogeropulou, Jing Zhao, Marc F. Bolliger, Anna Memou, Shreya Narasimha, Tyler P. Molitor, William H. Wilson, Hardy J. Rideout, R. Jeremy Nichols

Biochemical Journal Apr 2018, 475 (7) 1271-1293; DOI: 10.1042/BCJ20170699
Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease
Patrick A. Eyers

Biochemical Journal Jan 2018, 475 (1) 185-189; DOI: 10.1042/BCJ20170870
Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils
Ying Fan, Andrew J.M. Howden, Adil R. Sarhan, Pawel Lis, Genta Ito, Terina N. Martinez, Kathrin Brockmann, Thomas Gasser, Dario R. Alessi, Esther M. Sammler

Biochemical Journal Jan 2018, 475 (1) 23-44; DOI: 10.1042/BCJ20170803
Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase
Pawel Lis, Sophie Burel, Martin Steger, Matthias Mann, Fiona Brown, Federico Diez, Francesca Tonelli, Janice L. Holton, Philip Winglok Ho, Shu-Leong Ho, Meng-Yun Chou, Nicole K. Polinski, Terina N. Martinez, Paul Davies, Dario R. Alessi

Biochemical Journal Jan 2018, 475 (1) 1-22; DOI: 10.1042/BCJ20170802
Activation mechanisms of the E3 ubiquitin ligase parkin
Nikhil Panicker, Valina L. Dawson, Ted M. Dawson

Biochemical Journal Sep 2017, 474 (18) 3075-3086; DOI: 10.1042/BCJ20170476
The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2
Iakov N. Rudenko, Alice Kaganovich, Rebekah G. Langston, Aleksandra Beilina, Kelechi Ndukwe, Ravindran Kumaran, Allissa A. Dillman, Ruth Chia, Mark R. Cookson

Biochemical Journal May 2017, 474 (9) 1547-1558; DOI: 10.1042/BCJ20160909
Ubiquitin and Parkinson's disease through the looking glass of genetics
Helen Walden, Miratul M.K. Muqit

Biochemical Journal May 2017, 474 (9) 1439-1451; DOI: 10.1042/BCJ20160498
Structural interface between LRRK2 and 14-3-3 protein
Loes M. Stevers, Rens M.J.M. de Vries, Richard G. Doveston, Lech-Gustav Milroy, Luc Brunsveld, Christian Ottmann

Biochemical Journal Apr 2017, 474 (7) 1273-1287; DOI: 10.1042/BCJ20161078

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