Table 1 Structural homology of Pdx1

The structural homology search was performed with DALI using B. subtilis Pdx1 (PDB code 2NV2, chain A) as a query. The matched structures are sorted by the Z-score (i.e. the strength of structural similarity in S.D.s above expected). RMSD, positional root mean square deviation of superimposed Cα atoms in Å; LALI, total number of equivalenced residues; LSEQ2, length of the entire chain of the equivalenced structure; IDE, percentage of sequence identity over equivalenced positions.

ProteinOrganismPDB codeZ-scoreRMSDLALILSEQ2IDE (%)
Synthase subunit of PLP synthaseG. stearothermophilus1ZNN-A39.80.724324586
Thiamin phosphate synthase (TPS)B. subtilis2TPS-A17.82.719322619
Triose-phosphate isomerase (TIM)Pyrococcus woesei1HG3-A15.72.618022417
Pyridoxine 5′-phosphate synthase (PdxJ)E. coli1HO1-A15.32.91852359
Thiazole synthase (ThiG)B. subtilis1TYG-A14.72.718324217
Regulatory protein TenIB. subtilis1YAD-A14.52.516819015
Imidazole glycerol phosphate synthase (HisF)T. maritima1THF-D14.22.718225318
N-(5′phosphoribosyl) anthranilate isomerase/indole-3-glycerol phosphate synthaseE. coli1PII14.02.818445215
Indole-3-glycerol phosphate synthase (IGPS)Sulfolobus solfataricus1A5313.92.717624716
Isopentenyl-diphosphate:dimethylallyl diphosphate isomeraseB. subtilis1P0K-A13.72.618230616