Table 1 CG2791 and CD98hc have multiple conserved structural domains

Percentage identities between the three major structural domains conserved between Drosophila CG2791 and the human heavy-chain protein, CD98hc, and between CG2791 and the second human heavy-chain protein, rBAT [7]. Although there are comparable similarities between the amylase domain of CG2791 and those of CD98hc and rBAT, CG2791 and CD98hc show much greater similarity to each other in their extracellular domains and in the extended intracellular domain that is implicated in integrin binding [23].

RegionHuman CD98hcHuman rBAT
Novel intracellular domain46%21%
Transmembrane domain48%26%
Amylase-like domain11%13%
Total17%15%