Table 1 The size of the nine largest domain superfamilies in humans, the number of sequences in which they occur and the same data for these superfamilies in Fugu, Drosophila and C. elegans

In Drosophila, the superfamilies in rank positions 5, 6 and 9 are trypsin-like serine proteases (267 domains; 259 sequences), invertebrate chitin-binding proteins (260 domains; 87 sequences) and glucocorticoid receptor-like DNA-binding domains (206 domains; 145 sequences) respectively. In C. elegans, the superfamilies at rank positions 5, 6, 7, 8 and 9 are c-type lectins (356 domains; 280 sequences), glucocorticoid receptor-like DNA-binding domains (348 domains; 319 sequences), nuclear receptor ligand-binding domains (280 domains; 280 sequences); L domains (222 domains; 129 sequences) and MF (major facilitator) general transporters (216 domains; 214 sequences) respectively. The data in this Table are taken from the SUPERFAMILY database release 1.73. The total number of genes for each species are 2300 (human), 18500 (Fugu), 14100 (Drosophila) and 20100 (C. elegans). Abbreviations: EGF, epidermal growth factor; PH, pleckstrin homology.

HumanFuguDrosophilaC. elegans
Domain superfamilyDomainsSequencesRankDomainsSequencesRankDomainsSequencesRankDomainsSequencesRank
C2H2 and C2HC zinc fingers36937421949319451922321349123
Immunoglobulins17787962137949414901273360704
P-loop nucleoside triphosphate hydrolases102486131112958261849916214872
G-protein-coupled receptors: family A824824447047098484389709701
Fibronectin type III80218951042225319957101734012
EGF/laminin697183669518262094881455720
Cadherins686100789211352111971281624
Protein kinases5395268666651729529044864783
PH domains491410958750181521351812411727