Table 1 Amyloidogenic peptides involved in several amyloidogenic diseases
Associated disease (main)PeptideNumber of amino acidsMolecular mass (kDa)Biological roleDefined structure (yes/no)
AD39–434.6UnknownNo
PDα-Synuclein10111.4UnknownNo
T2DMIAPP374.2HormoneNo
Huntington's diseaseHuntingtin*>3000>330UnknownNo
ALSSOD115432EnzymeYes
Dialysis-related amyloidosisβ2-Microglobulin9911.6VariousYes
Non-neuropathic systemic amyloidosisLysozyme13015EnzymeYes
Meretoja's diseaseGelsoline78282RegulatoryYes
  • *Huntingtin includes a variable number of polyglutamine repeats. Proteins with >40 repeats aggregate to form amyloid fibrils.

  • †Also known as Finnish amyloidosis.