Table 1 Summary of inactivation parameters for Kv1.4-containing heteromers expressed in HEK-293 cells

Results recorded are presented as means±S.E.M., n-values are in brackets. *, values are significant, P<0.05 (Mann–Whitney U test).

Inactivation time constantsSteady state inactivationRecovery from inactivation
Channelsτ1inact at 10 mV (ms)τ2inact at 10 mV (ms)τ1inact at −10 mV (ms)τ2inact at −10 mV (ms)V1/2 (mV)Slope (k)τ at −90 mV (s)
Kv1.4–1.6–1.2–1.2220±16 (5)*3720±280340±20 (5)*4990±430−32±1 (5)*6±13.1±0.1(4)*
Kv1.4–1.2–1.2–1.6160±4 (7)*4000±790240±21 (7)*4120±340−31±1 (7)*10±12.6±0.04 (6)*
Kv1.4–1.2–1.2–1.2119±21 (4)2700±550155±34 (4)4270±110−49±0.5 (4)10±12.7±0.01 (4)
Kv1.4–1.6(mut)–1.2–1.2112±15 (5)2040±360190±20 (5)3090±570−37±1 (5)9±12.6±0.02 (4)
Kv1.4–1.2–1.6–1.2120±14 (7)*2970±690140±10 (7)*4060±480−40±1 (5)*10±12.2±0.1 (7)*
Kv1.4–1.2–1.6(mut)–1.2110±14 (4)2610±180210±40 (4)3990±650−37±1 (5)7±12.0±0.1 (4)