Table 1 Properties of thiolases of the six characterized human subfamilies

The PDB entry codes of known structures are provided.

ThiolasesLocationAssemblyFunctionSubstrateCommentReference
CT-thiolaseCytosolTetramerSyntheticAcetyl-CoAHomologue of the Z. ramgera thiolase (PDB code 1WL4)[8]
T1-thiolaseMitochondriaTetramerDegradativeLong-chain unbranched acyl-CoAStructure not known[28]
T2-thiolaseMitochondriaTetramerSynthetic and degradativeShort-chain 2-methyl-branched and unbranched acyl-CoAPDB code 2IBW[9]
AB-thiolasePeroxisomesDimerDegradativeLong-chain unbranched acyl-CoAHomologue of the S. cerevisae thiolase (PDB code 2IIK)[17]
SCP2-thiolasePeroxisomesDimerDegradativeLong-chain 2-methyl-branched and unbranched acyl-CoAStructure not known[29]
TFE-thiolaseMitochondriaDimerDegradativeLong-chain 2-methyl-branched and unbranched acyl-CoAStructure not known[30]