Table 4 High-resolution PKS ACP and NRPS PCP structures available
OrganismAcylation stateEnd productPDB ID
PKS
S. coelicolorApoActinorhodin2AF8, 2K0Y
Holo2K0X
Acetyl2KG6
Malonyl2KG8
3-Oxobutyl2KGD
3,5-Dioxobutyl2KGE
Butyryla2KG9
Hexanoyla2KGA
Octanoyla2KGC
S. rimosusApoOxytetracycline1NQ4
S. roseofulvusHoloFrenolicin1OR5
S. erythraeaApo6-Deoxyerythrololide Bb2JU1, 2JU2
A. parasiticusHoloNorsolorinic acid2KR5
NRPS
B. brevisHoloTyrocidine1DNY
Apo2GDY
Apo/holo2GDW
Holo2GDX
Apoc2JGP
E. coliApodEnterobactin2FQ1
Anabaena sp.ApoUnknown2AFD
Other
L. rhamnosusApoeLipoteichoic acid1DV5, 1HQB
  • a Non-native substrate

  • b This product is a building block of erythromycin

  • c Solved in a complex with a condensation domain

  • d Solved in a complex with an isochorismate lyase domain

  • e D-alanyl carrier protein