Table 1 PRH target genes
GeneRegulationModelMethodReferences
GoosecoidRepressedXenopus embryosEctopic expression[34]
ES tissue cultured cellsTransient transfection
ChordinRepressedXenopus embryosEctopic expression[34]
Xtle4, Nodal (Xnr1, Xnr2)RepressedXenopus embryosIn situ hybridization[35]
ES tissue cultured cellsEctopic expression
Conditional expression
Affymetrix gene chips
TgRepressedFRLT-5 tissue cultured cellsTransient transfection[28]
VEGEF, VEGFR-1, VEGFR-2, TIE-1, TIE-2, neuropilin-1, integrin αVRepressedHUVEC tissue cultured cellsAdenoviral infection[5557]
ES tissue cultured cellscDNA microarray analysis, quantitative real-time RT (reverse transcription)–PCR
ESM-1RepressedEOMA and HUVEC tissue cultured cellsTransient transfection[36]
Adenoviral infection
Quantitative real-time RT (reverse transcription)–PCR
OMM16K Genechip microarray
NTCPActivatedPRH knockout in E10.5 embryosTransient transfection[85]
L-PKActivatedHep G2 tissue cultured cellsTransient transfection[43]
HeLa cellsAdenoviral infection
Rat cultured hepatocytes
NIS (sodium iodide symporter)ActivatedHeLa cultured cellsTransient transfection[66]