Table 1 Comparison of TORC1 and TORC2 in S. cerevisiae, S. pombe and Homo sapiens

Conserved core components of each TORC and non-conserved interactors or proteins that associate with TOR directly or indirectly are included. Also listed are the AGC kinase targets linked to the TOR pathway either directly or indirectly and other non-AGC kinase targets that have been demonstrated to be phosphorylated in a TOR-dependent manner. (?) indicates orthologues that have not been shown to be part of or targeted by TORCs.

S. cerevisiaeS. pombeH. sapiens
TORC1TORC2TORC1TORC2TORC1TORC2
Conserved componentsTOR1TOR2Tor2Tor1mTORmTOR
TOR2
KOG1Mip1raptor
LST8LST8Wat1Wat1mLST8mLST8
AVO1Sin1SIN1
AVO3Ste20rictor
Non-conserved interactorsTCO89
AVO2
BIT61
BIT2
SLM1/2SPAC637.13 (?)
Mei2
Ste11
PRAS40
PRR5/PRR5L
AGC kinase targetSCH9Sck1/2 (?)S6K
PKC1Pck1/2 (?)cPKC
YPK1/2Gad8SGK (?)
Akt
Other targetsNPR1Oca2 (?)
GLN3
TAP42SPCC63.05 (?)
SLM1/2SPAC637.13 (?)
4E-BP
eEF2