Table 2 Subcellular localization of some histidine phosphatase superfamily members
BranchLocalizationProteinRepresentative speciesEvidence for localization
1CytosoldPGMHuman[4]
BPGMRat[124]
F26BPaseRat[125]
NuclearTFIIIC τ 55 kDa subunitS. cerevisiae[39]
Cytosol and nuclearUBASH3A/TULA/SRS-2Human[6,126]
PGAM5Human[38]
dPGMRat[127,128]
YOR283WS. cerevisiae[129]
YDR051CS. cerevisiae[129]
Cytosol and cell walldPGMS. cerevisiae[54]
PeriplasmAisE. coliPredicted in [53]
2LysosomeLysophosphatidic acid phosphataseHuman[130]
ER/plasma membraneMultiple inositol-polyphosphate phosphataseHuman[29,122]
Endosomal/lysosomal compartmentAPLeishmania mexicana[131]
Cell membrane (type I, catalytic domain outside cell)APLeishmania donovani[132]
Cell membrane (type I, catalytic domain outside cell)Testicular acid phosphataseHumanSwiss-Prot [56]
Cell wallThiamine-repressible acid phosphatase precursorS. pombe[133]
PeriplasmPhytaseE. coli[134]
Glucose-1-phosphataseE. coli[21]
SecretedPho5pS. cerevisiae[135]
PhytaseAspergillus ficuum[136]