Table 2 Effects of pH on the kinetic parameters for lactate-induced inhibition of skeletal muscle PFK

The parameters were calculated fitting eqn (1) to the experimental data obtained under the same conditions shown in Figure 1. *P<0.05 compared with pH 6.7, 7.0 or 7.4; †P<0.05 compared with pH 7.0 or 7.4; ‡P<0.05 compared with pH 6.5, 7.0 or 7.4; §P<0.05 compared with pH 6.5, 6.7 or 7.4; n.d. not determined.

pHI0.5 (mM)n
6.50.60±0.08*0.4±0.1†
6.71.2±0.1‡0.5±0.1†
7.03.0±0.3§0.7±0.1§
7.44.6±0.32.0±0.2
8.2n.d.n.d.