In issue 18 of the Biochemical Journal, Thomas et al. report on the interaction between AMPK and one of its target proteins TBC1D1. The research shows that the association is AMPK-isoform-specific and that it is disrupted by a mutation linked to obesity. The cover image, taken from the article, shows Western blot analysis of the phosphorylation of transiently expressed GFP-TBC1D1 as well as AMPK and ACC from Flp-In HEK293 cells that stably express FLAG-AMPK-α1 or FLAG-AMPK-α2.