Structure of the C-terminal part of C. elegans cyclase-associated protein (CAS-2) (top) was modeled as a dimer based on the structure of the C-terminal part of human CAP1 (bottom). Mutagenesis study revealed an essential role of the C-terminal dimerization motif for the actin-regulatory activities of CAS-2. Please see pp. 4427–4441 for further information. Image provided by S. Ono.