Module 8: Figure smooth muscle cell differentiation
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Control of smooth muscle differentiation.
Smooth muscle cells (SMCs) are highly plastic in that they can readily switch from a highly differentiated contractile smooth muscle phenotype to a more fibroblast-like proliferative phenotype. Serum-response factor (SRF), working together with the miR-143/miR-145 cluster, controls this proliferation/differentiation switch.