Exploring the molecular mechanisms that underpin key biological processes, the Biochemical Journal is a leading bioscience journal publishing high-impact scientific research papers and reviews on the latest advances and new mechanistic concepts in the fields of biochemistry, cellular biosciences and molecular biology.
We are committed to publishing work that provides a significant advance to current understanding or mechanistic insights; studies that go beyond observational work using in vitro and/or in vivo approaches are welcomed.
Areas covered include:
- Molecular Structure and Function
- Cell Biology
- Chemical Biology
- Mechanisms of Disease
- Energy Processes
- Gene Expression and Regulation
- Plant Biochemistry
- Signalling Pathways and Processes
Molecular Structure and Function – covering studies that provide structural and mechanistic insight into biological function. This includes enzymology, glycobiology, proteomes and interactomes (‘-omics’ research), structural biology. Modelling and molecular dynamics studies are welcome but should be accompanied by experimental verification.
Cell Biology – covering any aspect of cellular physiology, from how cells function, are organized and regulated, to how they fail under stress or in disease. This includes, but is not limited to, endo/exo-cytosis, membrane biology and trafficking, organelle biogenesis, migration, motility, growth, development, differentiation, the cytoskeleton, replication, trafficking, protein sorting, cell cycle and cell death. Research on specific tissues or cell types is also welcome.
Chemical Biology – covering any work identifying small-molecule inhibitors, activators and broader chemical tools (such as bioimaging probes, dyes, or proteomic tools) employed to interrogate biochemistry. It is critical that only research that goes beyond chemical analysis and provides some biological insights can be considered for publication. Work on new concepts or methods of drug discovery, design or delivery is also welcome as long as novel biological insight is provided.
Mechanisms of Disease – covering any research characterizing or treating the molecular, biochemical or physiological basis of disease, including translational work. This includes, but is not limited to, cancer, neurodegeneration, developmental and genetic disorders, disease models, infection and immunity, stem cells and gene therapy. The focus is on the mechanisms that lead to (or result from) the disease and the potential therapies that can improve outcome.
Energy Processes – covering cellular energy processes including redox signalling and/or oxidative stress, electron transport, energy transduction, bioenergetics, mitochondrial structure and function, autophagy, glycolysis and bacterial metabolism.
Gene Expression and Regulation – covering research into the function and regulation of DNA or RNAs, interactions with these molecules, gene technology, transcription and translation, replication and recombination, epigenetics, chromatin dynamics, transcriptome regulation, and synthetic biology. Expression data requires a broader biological or mechanistic insight.
Metabolism – covering biochemical mechanisms contributing to metabolic regulation from a cellular to systems level including (but not limited to) the study of metabolic disorders, cancer metabolism, inflammation, the microbiome, obesity, exercise and nutrition.
Plant Biochemistry – broadly covering research relating to the cellular, signalling or metabolic function of plants, including, but not limited to, photosynthesis, nitrogen fixation, cell walls, organelles, growth and development, and disease.
Signalling Pathways and Processes – covering research into intra- and inter-cellular signalling processes, their regulation, their consequences, and their dysfunction at the level of individual molecules and pathways and/or complete systems/networks. This includes, but is not limited to, Ca2+ signalling, lipid signalling, secondary messengers, kinases and post-translational modifications, growth factors, GPCRs, cytokines, integrins, small G-proteins, neurotransmitter signalling, hormones, nitric oxide, extracellular matrix signalling and transcription factors.