The hnRNPs (heterogeneous nuclear ribonucleoproteins) are RNA-binding proteins with important roles in multiple aspects of nucleic acid metabolism, including the packaging of nascent transcripts, alternative splicing and translational regulation. Although they share some general characteristics, they vary greatly in terms of their domain composition and functional properties. Although the traditional grouping of the hnRNPs as a collection of proteins provided a practical framework, which has guided much of the research on them, this approach is becoming increasingly incompatible with current knowledge about their structural and functional divergence. Hence, we review the current literature to examine hnRNP diversity, and discuss how this impacts upon approaches to the classification of RNA-binding proteins in general.
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September 2010
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Review Article|
August 27 2010
Functional diversity of the hnRNPs: past, present and perspectives
Siew Ping Han;
Siew Ping Han
1School of Chemistry and Molecular Biosciences, University of Queensland, Building 76, Cooper Road, Brisbane, Queensland 4072, Australia
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Yue Hang Tang;
Yue Hang Tang
1School of Chemistry and Molecular Biosciences, University of Queensland, Building 76, Cooper Road, Brisbane, Queensland 4072, Australia
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Ross Smith
1School of Chemistry and Molecular Biosciences, University of Queensland, Building 76, Cooper Road, Brisbane, Queensland 4072, Australia
1To whom correspondence should be addressed (email ross.s@uq.edu.au).
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Publisher: Portland Press Ltd
Received:
March 22 2010
Revision Received:
June 29 2010
Accepted:
June 29 2010
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2010 Biochemical Society
2010
Biochem J (2010) 430 (3): 379–392.
Article history
Received:
March 22 2010
Revision Received:
June 29 2010
Accepted:
June 29 2010
Citation
Siew Ping Han, Yue Hang Tang, Ross Smith; Functional diversity of the hnRNPs: past, present and perspectives. Biochem J 15 September 2010; 430 (3): 379–392. doi: https://doi.org/10.1042/BJ20100396
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