Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

Pawel Lis; Sophie Burel; Martin Steger; Matthias Mann; Fiona Brown; Federico Diez; Francesca Tonelli; Janice L. Holton; Philip Winglok Ho; Shu-Leong Ho; Meng-Yun Chou; Nicole K. Polinski; Terina N. Martinez; Paul Davies; Dario R. Alessi

doi:10.1042/BCJ20170802

Research article

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

Pawel Lis, Sophie Burel, Martin Steger, Matthias Mann, Fiona Brown, Federico Diez, Francesca Tonelli, Janice L. Holton, Philip Winglok Ho, Shu-Leong Ho, Meng-Yun Chou, Nicole K. Polinski, Terina N. Martinez, Paul Davies, Dario R. Alessi

Biochemical Journal Jan 02, 2018, 475 (1) 1-22; DOI: 10.1042/BCJ20170802

Pawel Lis

MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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For correspondence: p.lis@dundee.ac.ukd.r.alessi@dundee.ac.uk

Sophie Burel

MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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Martin Steger

Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Martinsried, Germany

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Matthias Mann

Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Martinsried, Germany

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Fiona Brown

MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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Federico Diez

MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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Francesca Tonelli

MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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Janice L. Holton

Division of Neuropathology, UCL Institute of Neurology, Queen Square, London, U.K.

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Philip Winglok Ho

Division of Neurology, Department of Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong

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Shu-Leong Ho

Division of Neurology, Department of Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong

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Meng-Yun Chou

Abcam, 863 Mitten Rd, Burlingame, CA 94010, U.S.A.

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Nicole K. Polinski

The Michael J. Fox Foundation for Parkinson's Research, Grand Central Station, PO Box 4777, New York, NY 10163, U.S.A.

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Terina N. Martinez

The Michael J. Fox Foundation for Parkinson's Research, Grand Central Station, PO Box 4777, New York, NY 10163, U.S.A.

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Paul Davies

MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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Dario R. Alessi

MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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For correspondence: p.lis@dundee.ac.ukd.r.alessi@dundee.ac.uk

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