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Research article

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

Pawel Lis, Sophie Burel, Martin Steger, Matthias Mann, Fiona Brown, Federico Diez, Francesca Tonelli, Janice L. Holton, Philip Winglok Ho, Shu-Leong Ho, Meng-Yun Chou, Nicole K. Polinski, Terina N. Martinez, Paul Davies, Dario R. Alessi
Biochemical Journal Jan 02, 2018, 475 (1) 1-22; DOI: 10.1042/BCJ20170802
Pawel Lis
MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
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  • For correspondence: p.lis@dundee.ac.ukd.r.alessi@dundee.ac.uk
Sophie Burel
MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
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Martin Steger
Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Martinsried, Germany
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Matthias Mann
Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Martinsried, Germany
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Fiona Brown
MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
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Federico Diez
MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
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Francesca Tonelli
MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
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Janice L. Holton
Division of Neuropathology, UCL Institute of Neurology, Queen Square, London, U.K.
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Philip Winglok Ho
Division of Neurology, Department of Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong
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Shu-Leong Ho
Division of Neurology, Department of Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong
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Meng-Yun Chou
Abcam, 863 Mitten Rd, Burlingame, CA 94010, U.S.A.
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Nicole K. Polinski
The Michael J. Fox Foundation for Parkinson's Research, Grand Central Station, PO Box 4777, New York, NY 10163, U.S.A.
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Terina N. Martinez
The Michael J. Fox Foundation for Parkinson's Research, Grand Central Station, PO Box 4777, New York, NY 10163, U.S.A.
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Paul Davies
MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
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Dario R. Alessi
MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
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  • For correspondence: p.lis@dundee.ac.ukd.r.alessi@dundee.ac.uk
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January 2018

Volume: 475 Issue: 1

Biochemical Journal: 475 (1)
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Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase
Pawel Lis, Sophie Burel, Martin Steger, Matthias Mann, Fiona Brown, Federico Diez, Francesca Tonelli, Janice L. Holton, Philip Winglok Ho, Shu-Leong Ho, Meng-Yun Chou, Nicole K. Polinski, Terina N. Martinez, Paul Davies, Dario R. Alessi
Biochemical Journal Jan 2018, 475 (1) 1-22; DOI: 10.1042/BCJ20170802
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Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase
Pawel Lis, Sophie Burel, Martin Steger, Matthias Mann, Fiona Brown, Federico Diez, Francesca Tonelli, Janice L. Holton, Philip Winglok Ho, Shu-Leong Ho, Meng-Yun Chou, Nicole K. Polinski, Terina N. Martinez, Paul Davies, Dario R. Alessi
Biochemical Journal Jan 2018, 475 (1) 1-22; DOI: 10.1042/BCJ20170802

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Keywords

antibodies
leucine-rich repeat kinase
Parkinson's disease
protein kinase
Rab GTPases
Rab10

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