Skip to main content

Main menu

  • Home
  • About the Journal
    • General Information
    • Scope
    • Editorial Board
    • Impact & Metrics
    • Benefits of Publishing
    • Advertising/Sponsorship
    • About the Biochemical Society
  • Current Issue
  • For Authors
    • Submit Your Paper
    • Submission Guidelines
    • Editorial Policy
    • Open Access Policy
    • Rights and Permissions
    • Biochemical Society Member Benefits
  • For Librarians
    • Subscriptions and Pricing
    • Check Your Usage
    • Terms and Conditions
      • Biochemical Journal- Terms and Conditions of Usage
    • Open Access Policy
    • FAQs for Librarians
    • Register for Free Trial
  • For Readers
    • Subscribe
    • Rights and Permissions
    • Biochemical Society Member Benefits
    • Journal Access for Biochemical Society Members
    • Request a Free Trial
  • Collections
    • Article Collections
    • Classic Articles
  • Help
    • Technical Support
    • Contact Us
  • Other Publications
    • NEW: Emerging Topics in Life Sciences
    • NEW: Neuronal Signaling
    • Clinical Science
    • Biochemical Journal
    • Biochemical Society Transactions
    • Bioscience Reports
    • Essays in Biochemistry
    • Biochemical Society Symposia
    • Cell Signalling Biology
    • Glossary of Biochemistry and Molecular Biology
    • The Biochemist
    • Biochemical Society

User menu

  • Log-in
  • Subscribe
  • Contact Us

Search

  • Advanced search
  • Other Publications
    • NEW: Emerging Topics in Life Sciences
    • NEW: Neuronal Signaling
    • Clinical Science
    • Biochemical Journal
    • Biochemical Society Transactions
    • Bioscience Reports
    • Essays in Biochemistry
    • Biochemical Society Symposia
    • Cell Signalling Biology
    • Glossary of Biochemistry and Molecular Biology
    • The Biochemist
    • Biochemical Society

Log-in

Sign-up for alerts  
  • My Cart
Biochemical Journal
Browse Archive
Advanced Search
  • Home
  • About the Journal
    • General Information
    • Scope
    • Editorial Board
    • Impact & Metrics
    • Benefits of Publishing
    • Advertising/Sponsorship
    • About the Biochemical Society
  • Current Issue
  • For Authors
    • Submit Your Paper
    • Submission Guidelines
    • Editorial Policy
    • Open Access Policy
    • Rights and Permissions
    • Biochemical Society Member Benefits
  • For Librarians
    • Subscriptions and Pricing
    • Check Your Usage
    • Terms and Conditions
    • Open Access Policy
    • FAQs for Librarians
    • Register for Free Trial
  • For Readers
    • Subscribe
    • Rights and Permissions
    • Biochemical Society Member Benefits
    • Journal Access for Biochemical Society Members
    • Request a Free Trial
  • Collections
    • Article Collections
    • Classic Articles
  • Help
    • Technical Support
    • Contact Us

Review article

The lysosome: a crucial hub for AMPK and mTORC1 signalling

Bernadette Carroll, Elaine A. Dunlop
Biochemical Journal Apr 13, 2017, 474 (9) 1453-1466; DOI: 10.1042/BCJ20160780
Bernadette Carroll
Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, U.K.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • View author's works on this site
Elaine A. Dunlop
Division of Cancer and Genetics, Cardiff University, Cardiff, U.K.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • View author's works on this site
  • For correspondence: dunlopea@cardiff.ac.uk
  • Article
  • Figures
  • Info & Metrics
  • PDF
Loading

Abstract

Much attention has recently been focussed on the lysosome as a signalling hub. Following the initial discovery that localisation of the nutrient-sensitive kinase, mammalian target of rapamycin complex 1 (mTORC1), to the lysosome was essential for mTORC1 activation, the field has rapidly expanded to reveal the role of the lysosome as a platform permitting the co-ordination of several homeostatic signalling pathways. Much is now understood about how the lysosome contributes to amino acid sensing by mTORC1, the involvement of the energy-sensing kinase, AMP-activated protein kinase (AMPK), at the lysosome and how both AMPK and mTORC1 signalling pathways feedback to lysosomal biogenesis and regeneration following autophagy. This review will cover the classical role of the lysosome in autophagy, the dynamic signalling interactions which take place on the lysosomal surface and the multiple levels of cross-talk which exist between lysosomes, AMPK and mTORC1.

  • AMPK
  • autophagy
  • lysosomes
  • mTORC1
  • signalling
  • Abbreviations

    α-KG,
    α-ketoglutarate;
    ALG-2,
    asparagine-linked glycosylation 2;
    AMPK,
    AMP-activated protein kinase;
    ATG,
    autophagy-related;
    DEPTOR,
    DEP domain containing mTOR-interacting protein;
    ERK,
    extracellular signal-regulated kinase;
    FLCN,
    folliculin;
    GAP,
    GTPase-activating protein;
    GATOR,
    GTPase-activating protein activity towards Rags;
    GDI,
    guanine nucleotide dissociation inhibitor;
    GEF,
    guanine nucleotide exchange factor;
    LAMP,
    lysosomal-associated membrane protein;
    LAMTOR,
    late endosomal/lysosomal adaptor, MAPK and mTOR activator;
    LAT1,
    L-type amino acid transporter 1;
    LC3,
    microtubule-associated protein 1A/1B-light chain 3;
    LKB1,
    liver kinase B1;
    MEK,
    mitogen-activated protein kinase/ERK kinase;
    MITF,
    microphthalmia-associated transcription factor;
    MO25,
    mouse protein 25;
    mTORC1,
    mechanistic (mammalian) target of rapamycin complex 1;
    PAT,
    proton-assisted amino acid transporter;
    PI3K,
    phosphoinositide 3-kinase;
    Raptor,
    regulatory-associated protein of mTOR;
    PI(3,5)P2,
    phosphatidylinositol 3,5-bisphosphate;
    Rheb,
    Ras homologue enriched in brain;
    SESN,
    sestrin;
    SLC3A2,
    solute carrier family 3, member 2;
    SLC7A5,
    solute carrier family 7, member 5;
    SNAP,
    synaptosomal-associated protein;
    SNARE,
    soluble N-ethylmaleimide-sensitive factor-activating protein receptor;
    STRAD,
    Ste20-related adaptor;
    STX,
    syntaxin;
    TFEB,
    transcription factor EB;
    TRPML1,
    transient receptor potential cation channel, mucolipid subfamily;
    TSC,
    tuberous sclerosis complex;
    ULK1,
    Unc51-like kinase;
    UVRAG,
    UV irradiation resistance-associated gene;
    VAMP,
    vesicle-associated membrane protein;
    v-ATPase,
    vacuolar H+-ATPase.
    • © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
    View Full Text

    Log in using your username and password

    Enter your Biochemical Journal username.
    Enter the password that accompanies your username.
    Forgot your user name or password?

    Log in through your institution

    You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
    If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.
    Previous ArticleNext Article
    Back to top

     

     

    May 2017

    Volume: 474 Issue: 9

    Biochemical Journal: 474 (9)
    • Table of Contents
    • About the Cover
    • Index by author

    Actions

    Email

    Thank you for your interest in spreading the word about Biochemical Journal.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    The lysosome: a crucial hub for AMPK and mTORC1 signalling
    (Your Name) has forwarded a page to you from Biochemical Journal
    (Your Name) thought you would like to see this page from the Biochemical Journal web site.
    Share
    The lysosome: a crucial hub for AMPK and mTORC1 signalling
    Bernadette Carroll, Elaine A. Dunlop
    Biochemical Journal May 2017, 474 (9) 1453-1466; DOI: 10.1042/BCJ20160780
    del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Facebook logo Mendeley logo
    Citation Tools
    The lysosome: a crucial hub for AMPK and mTORC1 signalling
    Bernadette Carroll, Elaine A. Dunlop
    Biochemical Journal May 2017, 474 (9) 1453-1466; DOI: 10.1042/BCJ20160780

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Print
    Alerts

    Please log in to add an alert for this article.

    Request Permissions
    Save to my folders

    View Full PDF

     Open in Utopia Docs
    • Tweet Widget
    • Facebook Like

    Jump To

    • Article
      • Abstract
      • What is the lysosome?
      • The role of the lysosome in autophagy
      • mTORC1 regulates protein homeostasis and cell growth
      • Cross-talk between autophagy and mTORC1
      • AMPK signalling and energy homeostasis
      • Summary
      • Funding
      • Competing Interests
      • References
    • Figures
    • Info & Metrics
    • PDF

    Keywords

    AMPK
    autophagy
    lysosomes
    mTORC1
    signalling

    Related Articles

    Cited By...

    • Portland Press Homepage
    • Publish With Us
    • Advertising
    • Technical Support
    • Biochemical Journal
    • Clinical Science
    • Essays in Biochemistry
    • Emerging Topics in Life Sciences
    • Biochemical Society Transactions
    • Neuronal Signaling
    • Bioscience Reports
    • Cell Signalling Biology
    • Biochemical Society Symposia

    Portland Press Limited
    Charles Darwin House
    12 Roger Street
    London WC1N 2JU
    Tel: +44(0) 20 7685 2410
    Fax: +44(0) 20 7685 2469
    Email: editorial@portlandpress.com

    The Biochemical Society