Epigenetic control via histone methylation is important in transcriptional regulation and occurs in the nucleus. However, this process can be regulated spatially by a protein localized in the Golgi apparatus. Subcellular compartmentalization can therefore affect epigenetic modification.
- Golgi apparatus
- H3 lysine 4 (H3K4) methylation
- progestin and adipoQ receptors member 3 (PAQR3)
- transcriptional regulation
Abbreviations: ASH2, absent, small or homoeotic discs 2; COMPASS, complex of proteins associated with Set1; C-ter, C-terminus of MLL1; EMT, epithelial–mesenchymal transition; GPCR, G-protein-coupled receptor; H3K4, histone H3 lysine 4; H3K4me2, H3K4 dimethylation; H3K4me3, H3K4 trimethylation; HDAC, histone deacetylase; HEK, human embryonic kidney; MLL, mixed-lineage leukaemia; PAQR, progestin and adipoQ receptors member; RBBP5, retinoblastoma-binding protein 5; RT, reverse transcription; WDR5, WD40 repeat-containing protein 5; Win, WDR5-interaction; WRAD, WDR5–ASH2–RBBP5–DPY30
- © The Authors Journal compilation © 2015 Biochemical Society