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Research article

Vimentin supports mitochondrial morphology and organization

Ho Lam Tang, Hong Lok Lung, Ka Chun Wu, Anh-Huy Phan Le, Ho Man Tang, Ming Chiu Fung
Biochemical Journal Jan 29, 2008, 410 (1) 141-146; DOI: 10.1042/BJ20071072
Ho Lam Tang
Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong
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Hong Lok Lung
Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
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Ka Chun Wu
Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong
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Anh-Huy Phan Le
Department of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, U.S.A.
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Ho Man Tang
Department of Biology, The Chinese University of Hong Kong, Shatin, Hong KongDepartment of Biology, Iowa State University of Science and Technology, Ames, IA 50011, U.S.A.
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Ming Chiu Fung
Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong
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  • For correspondence: mingchiufung@cuhk.edu.hk
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Abstract

Vimentin is one of the intermediate filaments that functions in structural support, signal transduction and organelle positioning of a cell. In the present study, we report the contribution of vimentin in mitochondrial morphology and organization. Using subcellular fractionation, immunoprecipitation and fluorescence microscopy analyses, we found that vimentin was associated with mitochondria. Knockdown of vimentin resulted in mitochondrial fragmentation, swelling and disorganization. We further demonstrated that the vimentin cytoskeleton co-localized and interacted with mitochondria to a greater extent than other cytoskeletal components known to support mitochondria. Our results also suggest that vimentin could participate in the mitochondrial association of microtubules. As mitochondrial morphologies determine mitochondrial function, our findings revealed a potentially important relationship between the vimentin-based intermediate filaments and the regulation of mitochondria.

  • cytoskeleton
  • interaction
  • intermediate filament
  • microtubule
  • mitochondrion
  • vimentin

Abbreviations: Bak, Bcl-2 antagonist/killer 1; Cox IV, cytochrome c oxidase complex IV; ER, endoplasmic reticulum; F-actin, filamentous actin; LDH, lactate dehydrogenase; PCNA, proliferating-cell nuclear antigen; RNAi, RNA interference; siRNA, small interfering RNA

  • © The Authors Journal compilation © 2008 Biochemical Society
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February 2008

Volume: 410 Issue: 1

Biochemical Journal: 410 (1)
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Vimentin supports mitochondrial morphology and organization
Ho Lam Tang, Hong Lok Lung, Ka Chun Wu, Anh-Huy Phan Le, Ho Man Tang, Ming Chiu Fung
Biochemical Journal Feb 2008, 410 (1) 141-146; DOI: 10.1042/BJ20071072
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Vimentin supports mitochondrial morphology and organization
Ho Lam Tang, Hong Lok Lung, Ka Chun Wu, Anh-Huy Phan Le, Ho Man Tang, Ming Chiu Fung
Biochemical Journal Feb 2008, 410 (1) 141-146; DOI: 10.1042/BJ20071072

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Keywords

cytoskeleton
interaction
intermediate filament
microtubule
mitochondrion
vimentin

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