Biochemical Journal

Review article

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

Alexandra C. NEWTON

Abstract

Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.

  • phosphoinositide 3-kinase
  • phosphoinositide-dependent kinase-1 (PDK-1)
  • phosphorylation motif
  • protein kinase A (PKA)
  • protein kinase B (PKB)/Akt
  • protein kinase C (PKC)

Footnotes

  • Abbreviations used: PDK-1, phosphoinositide-dependent kinase-1; PH, pleckstrin homology; PI 3-kinase, phosphoinositide 3-kinase; PIF, PDK-1-interacting fragment; PIP3, phosphatidylinositol 3,4,5-trisphosphate; PKA/PKB/PKC, protein kinases A, B and C respectively; PRK, PKC-related kinase.