Biochemical Journal

Research communication

Cytosolic aspartate aminotransferase gene is a member of the glucose-regulated protein gene family in adipocytes

Emmanuelle PLEE-GAUTIER, Hélène GRIMAL, Martine AGGERBECK, Robert BAROUKI, Claude FOREST


Stress controls the expression of a cohort of genes. Among these, the glucose-regulated protein (GRP) genes are specifically activated by glucose deprivation, reducing agents, glycosylation block, intracellular calcium or ex vivo incubations of tissues or cells. We demonstrate that these stimuli induce the expression of the cytosolic aspartate aminotransferase gene in adipocytes by a process involving the region of the promoter between -2405 and -26 bp. Therefore this transaminase is a new member of the GRP family.