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Research article

Cloning of a novel membrane-linked metalloproteinase from human myeloma cells

Norman McKIE, Donna J DALLAS, Tracy EDWARDS, Jane F APPERLEY, Graham G. RUSSELL, Peter I CROUCHER
Biochemical Journal Sep 01, 1996, 318 (2) 459-462; DOI: 10.1042/bj3180459
Norman McKIE
Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, U.K.
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Donna J DALLAS
Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, U.K.
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Tracy EDWARDS
Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, U.K.
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Jane F APPERLEY
Department of Haematology, Royal Postgraduate Medical School, Du Cane Road, London W12 0NN, U.K.
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Graham G. RUSSELL
Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, U.K.
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Peter I CROUCHER
Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, U.K.
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Abstract

We have isolated a novel cDNA from human myeloma cells encoding a member of the reprolysin family of metalloproteinases. Derived amino acid sequence predicts a protein of approx. 76 kDa. The open reading frame predicts the presence of a leader peptide, a pro-peptide with a ‘cysteine switch’, a metalloproteinase domain, a disintegrin-like domain, a cysteine-rich domain, an epidermal growth factor-like domain and a putative transmembrane sequence. Expression of the mRNA for this metalloproteinase has been demonstrated in human myeloma cells.

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September 1996

Volume: 318 Issue: 2

Biochemical Journal: 318 (2)
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Cloning of a novel membrane-linked metalloproteinase from human myeloma cells
Norman McKIE, Donna J DALLAS, Tracy EDWARDS, Jane F APPERLEY, Graham G. RUSSELL, Peter I CROUCHER
Biochemical Journal Sep 1996, 318 (2) 459-462; DOI: 10.1042/bj3180459
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Cloning of a novel membrane-linked metalloproteinase from human myeloma cells
Norman McKIE, Donna J DALLAS, Tracy EDWARDS, Jane F APPERLEY, Graham G. RUSSELL, Peter I CROUCHER
Biochemical Journal Sep 1996, 318 (2) 459-462; DOI: 10.1042/bj3180459

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