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Is respiratory activity in the brain mitochondria responsive to thyroid hormone action?: a critical re-evaluation

S S Katyare, C S Bangur, J L Howland
Biochemical Journal Sep 15, 1994, 302 (3) 857-860; DOI: 10.1042/bj3020857
S S Katyare
*Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Baroda 390 002, India
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C S Bangur
*Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Baroda 390 002, India
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J L Howland
†Committee on Biochemistry, Bowdoin College, Brunswick, ME 04011, U.S.A.
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Abstract

The effects of in vivo treatment with graded doses (0.5-1.5 micrograms/g body weight) of thyroid hormones, tri-iodothyronine (T3) and thyroxine (T4), for 4 consecutive days to euthyroid rats on the respiratory activity of isolated brain mitochondria were examined. T4 stimulated coupled State-3 respiration with glutamate, pyruvate + malate, ascorbate + tetramethyl-p-phenylenediamine and succinate, in a dose-dependent manner; T3 was effective only at the highest (1.5 micrograms) dose employed. T4 was more effective than T3 in stimulating respiratory activity. State-4 respiratory rates were in general not influenced except in the case of the ascorbate + tetramethyl-p-phenylenediamine system. Primary dehydrogenase activities, i.e. glutamate dehydrogenase, malate dehydrogenase and succinate dehydrogenase, were stimulated about 2-fold; interestingly mitochondrial but not cytosolic malate dehydrogenase activity was influenced under these conditions. The hormone treatments did not greatly influence the mitochondrial cytochrome content. The results therefore suggest that thyroid hormone treatment not only stimulates primary dehydrogenase activities but may also directly influence the process of mitochondrial electron transfer.

  • © 1994 The Biochemical Society, London
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September 1994

Volume: 302 Issue: 3

Biochemical Journal: 302 (3)
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Is respiratory activity in the brain mitochondria responsive to thyroid hormone action?: a critical re-evaluation
S S Katyare, C S Bangur, J L Howland
Biochemical Journal Sep 1994, 302 (3) 857-860; DOI: 10.1042/bj3020857
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Is respiratory activity in the brain mitochondria responsive to thyroid hormone action?: a critical re-evaluation
S S Katyare, C S Bangur, J L Howland
Biochemical Journal Sep 1994, 302 (3) 857-860; DOI: 10.1042/bj3020857

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