Output of 14CO2 from 1-14C-labelled glutamate, 2-oxoglutarate or octanoate and from 4-methyl-2-oxo[2-14C]pentanoate was increased by more than 100% after infusion of phenylephrine into perfused livers of fed rats. Infusion of ethanol or sorbitol raised 3-hydroxybutyrate/acetoacetate ratios and decreased the output of 14CO2. Increases in 14CO2 output induced by phenylephrine were observed in the presence or absence of ethanol or sorbitol and were accompanied by elevated 3-hydroxybutyrate/acetoacetate ratios under all conditions examined. Phenylephrine had no effect on total tissue ATP/ADP ratios in livers from fed or starved rats. The data suggest that phenylephrine-induced increases in tricarboxylic acid-cycle flux do not arise from lowered matrix NADH/NAD+ or ATP/ADP ratios.
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January 1986
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Research Article|
January 15 1986
The stimulation of tricarboxylic acid-cycle flux by α-adrenergic agonists in perfused rat liver
Publisher: Portland Press Ltd
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 1986 London: The Biochemical Society
1986
Biochem J (1986) 233 (2): 321–324.
Citation
W M Taylor, E van de Pol, F L Bygrave; The stimulation of tricarboxylic acid-cycle flux by α-adrenergic agonists in perfused rat liver. Biochem J 15 January 1986; 233 (2): 321–324. doi: https://doi.org/10.1042/bj2330321
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