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Volume 452

Volume 451

 The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Akihito Ohta, Frances‑Rose Schumacher, Youcef Mehellou, Clare Johnson, Axel Knebel, Thomas J. Macartney, Nicola T. Wood, Dario R. Alessi and Thimo Kurz..........111‑122

Published as BJ Immediate Publication 6 February 2013, doi:10.1042/BJ20121903

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 Saltatory formation, sliding and dissolution of ER–PM junctions in migrating cancer cells

Hayley Dingsdale, Emmanuel Okeke, Muhammad Awais, Lee Haynes, David N. Criddle, Robert Sutton and Alexei V. Tepikin..........25‑32

Published as BJ Immediate Publication 16 January 2013, doi:10.1042/BJ20121864

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 The mannose 6-phosphate-binding sites of M6P/IGF2R determine its capacity to suppress matrix invasion by squamous cell carcinoma cells

Olivia C. Probst, Evren Karayel, Nicole Schida, Elisabeth Nimmerfall, Elisabeth Hehenberger, Verena Puxbaum and Lukas Mach..........91‑99

Published as BJ Immediate Publication 25 January 2013, doi:10.1042/BJ20121422

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Volume 450

 The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

Claudia Broder and Christoph Becker‑Pauly..........253‑264

Published on the Internet 15 February 2013, doi:10.1042/BJ20121751

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 Exploring the sequence–structure relationship for amyloid peptides

Kyle L. Morris, Alison Rodger, Matthew R. Hicks, Maya Debulpaep, Joost Schymkowitz, Frederic Rousseau and Louise C. Serpell..........275‑283

Published as BJ Immediate Publication 20 December 2012, doi:10.1042/BJ20121773

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 High-resolution NMR studies of structure and dynamics of human ERp27 indicate extensive interdomain flexibility

Nader T. Amin, A. Katrine Wallis, Stephen A. Wells, Michelle L. Rowe, Richard A. Williamson, Mark J. Howard and Robert B. Freedman..........321‑332

Published as BJ Immediate Publication 12 December 2012, doi:10.1042/BJ20121635

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 p90 Ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G_q-protein-coupled receptor stimuli, endothelin-1 and α₁-adrenergic receptor agonists

Emre Amirak, Stephen J. Fuller, Peter H. Sugden and Angela Clerk..........351‑363

Published as BJ Immediate Publication 10 December 2012, doi:10.1042/BJ20121371

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 Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region

Deshun Gong, Fan Yang, Fudong Li, Dandan Qian, Minhao Wu, Zhenhua Shao, Mian Wu, Jihui Wu and Yunyu Shi..........85‑94

Published as BJ Immediate Publication 28 November 2012, doi:10.1042/BJ20121382

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Volume 449

 Rfa2 is specifically dephosphorylated by Pph3 in Candida albicans

Haitao Wang, Jiaxin Gao, Ada Hang‑Heng Wong, Kangdi Hu, Wanjie Li, Yue Wang and Jianli Sang..........673‑681

Published as BJ Immediate Publication 9 November 2012, doi:10.1042/BJ20120952

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 Generation and characterization of a lysosomally targeted, genetically encoded Ca²⁺-sensor

Hannah V. McCue, Joanna D. Wardyn, Robert D. Burgoyne and Lee P. Haynes..........449‑457

Published as BJ Immediate Publication 25 October 2012, doi:10.1042/BJ20120898

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 Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner

Lihua Jin, Christin L. Hanigan, Yu Wu, Wei Wang, Ben Ho Park, Patrick M. Woster and Robert A. Casero..........459‑468

Published as BJ Immediate Publication 17 October 2012, doi:10.1042/BJ20121360

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 Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment

Martin Zoltner, Paul K. Fyfe, Tracy Palmer and William N. Hunter..........469‑477

Published as BJ Immediate Publication 25 October 2012, doi:10.1042/BJ20121209

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 The severity of mammary gland developmental defects is linked to the overall functional status of Cx43 as revealed by genetically modified mice

Michael K. G. Stewart, Xiang‑Qun Gong, Kevin J. Barr, Donglin Bai, Glenn I. Fishman and Dale W. Laird..........401‑413

Published as BJ Immediate Publication 18 October 2012, doi:10.1042/BJ20121070

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 CFTR mutations altering CFTR fragmentation

Kendra Tosoni, Michelle Stobbart, Diane M. Cassidy, Andrea Venerando, Mario A. Pagano, Simão Luz, Margarida D. Amaral, Karl Kunzelmann, Lorenzo A. Pinna, Carlos M. Farinha and Anil Mehta..........295‑305

Published as BJ Immediate Publication 15 October 2012, doi:10.1042/BJ20121240

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 TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling

Niall S. Kenneth, Sharon Mudie, Sanne Naron and Sonia Rocha..........275‑284

Published as BJ Immediate Publication 27 September 2012, doi:10.1042/BJ20120625

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 Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

Guillermo Senisterra, Hong Wu, Abdellah Allali‑Hassani, Gregory A. Wasney, Dalia Barsyte‑Lovejoy, Ludmila Dombrovski, Aiping Dong, Kong T. Nguyen, David Smil, Yuri Bolshan, Taraneh Hajian, Hao He, Alma Seitova, Irene Chau, Fengling Li, Gennadiy Poda, Jean‑François Couture, Peter J. Brown, Rima Al‑Awar, Matthieu Schapira, Cheryl H. Arrowsmith and Masoud Vedadi..........151‑159

Published as BJ Immediate Publication 19 September 2012, doi:10.1042/BJ20121280

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Volume 448

 The substrate/product-binding modes of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485

Chun‑Hsiang Huang, Yu Sun, Tzu‑Ping Ko, Chun‑Chi Chen, Yingying Zheng, Hsiu‑Chien Chan, Xuefei Pang, Juergen Wiegel, Weilan Shao and Rey‑Ting Guo..........401‑407

Published as BJ Immediate Publication 20 September 2012, doi:10.1042/BJ20121359

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 Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain

Jin H. Park, Yingting Liu, Mark A. Lemmon and Ravi Radhakrishnan..........417‑423

Published as BJ Immediate Publication 29 October 2012, doi:10.1042/BJ20121513

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 2-APB-potentiated channels amplify CatSper-induced Ca²⁺ signals in human sperm

Linda Lefièvre, Katherine Nash, Steven Mansell, Sarah Costello, Emma Punt, Joao Correia, Jennifer Morris, Jackson Kirkman‑Brown, Stuart M. Wilson, Christopher L. R. Barratt and Stephen Publicover..........189‑200

Published as BJ Immediate Publication 3 September 2012, doi:10.1042/BJ20120339

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 Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family

Stephen C. Artim, Jeannine M. Mendrola and Mark A. Lemmon..........213‑220

Published as BJ Immediate Publication 20 September 2012, doi:10.1042/BJ20121365

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 A novel dual-fluorescence strategy for functionally validating microRNA targets in 3′ untranslated regions: regulation of the inward rectifier potassium channel K_ir2.1 by miR-212

Dana Goldoni, Janet M. Yarham, Mary K. McGahon, Anna O’Connor, Jasenka Guduric‑Fuchs, Kevin Edgar, Denise M. McDonald, David A. Simpson and Anthony Collins..........103‑113

Published as BJ Immediate Publication 13 August 2012, doi:10.1042/BJ20120578

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Volume 447

 The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases

Déborah Bréa, François Meurens, Alice V. Dubois, Julien Gaillard, Claire Chevaleyre, Marie‑Lise Jourdan, Nathalie Winter, Brigitte Arbeille, Mustapha Si‑Tahar, Francis Gauthier and Sylvie Attucci..........363‑370

Published as BJ Immediate Publication 6 August 2012, doi:10.1042/BJ20120818

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 Farnesyl diphosphate synthase, the target for nitrogen-containing bisphosphonate drugs, is a peroxisomal enzyme in the model system Dictyostelium discoideum

James M. Nuttall, Ewald H. Hettema and Donald J. Watts..........353‑361

Published as BJ Immediate Publication 31 July 2012, doi:10.1042/BJ20120750

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 Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas Gβγ subunits exert opposing effects depending on the G-protein source

Jia X. Shen, Sebastian Wachten, Michelle L. Halls, Katy L. Everett and Dermot M. F. Cooper..........393‑405

Published as BJ Immediate Publication 20 August 2012, doi:10.1042/BJ20120279

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 Dedifferentiated follicular granulosa cells derived from pig ovary can transdifferentiate into osteoblasts

Yoshinao Oki, Hiromasa Ono, Takeharu Motohashi, Nobuki Sugiura, Hiroyuki Nobusue and Koichiro Kano..........239‑248

Published as BJ Immediate Publication 27 July 2012, doi:10.1042/BJ20120172

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 Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

Masato Ogura, Junko Yamaki, Miwako K. Homma and Yoshimi Homma..........281‑289

Published as BJ Immediate Publication 24 July 2012, doi:10.1042/BJ20120509

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 A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples

Gaëtan Chicanne, Sonia Severin, Cécile Boscheron, Anne‑Dominique Terrisse, Marie‑Pierre Gratacap, Frédérique Gaits‑Iacovoni, Hélène Tronchère and Bernard Payrastre..........17‑23

Published as BJ Immediate Publication 25 July 2012, doi:10.1042/BJ20120945

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 Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

Ivan H. W. Ng, Dominic C. H. Ng, David A. Jans and Marie A. Bogoyevitch..........125‑136

Published as BJ Immediate Publication 17 July 2012, doi:10.1042/BJ20120941

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Volume 446

 Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents

Philip M. Kubara, Sophie Kernéis‑Golsteyn, Aurélie Studény, Brittany B. Lanser, Laurent Meijer and Roy M. Golsteyn..........373‑381

Published as BJ Immediate Publication 11 June 2012, doi:10.1042/BJ20120385

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 Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells

Kyubo Kim, Youlia M. Petrova, Brenton L. Scott, Rupesh Nigam, Anurag Agrawal, Christopher M. Evans, Zoulikha Azzegagh, Alejandra Gomez, Elsa M. Rodarte, Vesa M. Olkkonen, Rustam Bagirzadeh, Lucia Piccotti, Binhui Ren, Joo‑Heon Yoon, James A. McNew, Roberto Adachi, Michael J. Tuvim and Burton F. Dickey..........383‑394

Published as BJ Immediate Publication 14 June 2012, doi:10.1042/BJ20120057

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 Crystal structure of the dopamine N-acetyltransferase–acetyl-CoA complex provides insights into the catalytic mechanism

Kuo‑Chang Cheng, Jhen‑Ni Liao and Ping‑Chiang Lyu..........395‑404

Published as BJ Immediate Publication 21 June 2012, doi:10.1042/BJ20120520

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 Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties

Marianne Schimpl, Christina L. Rush, Marie Betou, Ian M. Eggleston, Anneliese D. Recklies and Daan M. F. van Aalten..........149‑157

Published as BJ Immediate Publication 28 June 2012, doi:10.1042/BJ20120377

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 Myostatin is a novel tumoral factor that induces cancer cachexia

Sudarsanareddy Lokireddy, Isuru Wijerupage Wijesoma, Sabeera Bonala, Meng Wei, Siu Kwan Sze, Craig McFarlane, Ravi Kambadur and Mridula Sharma..........23‑36

Published as BJ Immediate Publication 23 May 2012, doi:10.1042/BJ20112024

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 Intestinal peptidases form functional complexes with the neutral amino acid transporter B⁰AT1

Stephen J. Fairweather, Angelika Bröer, Megan L. O'Mara and Stefan Bröer..........135‑148

Published as BJ Immediate Publication 7 June 2012, doi:10.1042/BJ20120307

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Volume 445

 Solution structure of the core SMN–Gemin2 complex

Kathryn L. Sarachan, Kathleen G. Valentine, Kushol Gupta, Veronica R. Moorman, John M. Gledhill, Matthew Bernens, Cecilia Tommos, A. Joshua Wand and Gregory D. Van Duyne..........361‑370

Published as BJ Immediate Publication 21 May 2012, doi:10.1042/BJ20120241

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 Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2

Haiyan Sun, Choon‑myung Lee, Shweta Tripathi, Kyung‑Bo Kim and Edward T. Morgan..........377‑382

Published as BJ Immediate Publication 22 May 2012, doi:10.1042/BJ20120820

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 TGF-β sensitivity is determined by N-linked glycosylation of the type II TGF-β receptor

Young‑Woong Kim, Jinah Park, Hyun‑Ju Lee, So‑Young Lee and Seong‑Jin Kim..........403‑411

Published as BJ Immediate Publication 10 May 2012, doi:10.1042/BJ20111923

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 Different molecular bases underlie the mitochondrial respiratory activity in the homoeothermic spadices of Symplocarpus renifolius and the transiently thermogenic appendices of Arum maculatum

Yusuke Kakizaki, Anthony L. Moore and Kikukatsu Ito..........237‑246

Published as BJ Immediate Publication 19 April 2012, doi:10.1042/BJ20111978

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Volume 444

 Glycosylation at Asn⁹¹ of H1N1 haemagglutinin affects binding to glycan receptors

Akila Jayaraman, Xiaoying Koh, Jing Li, Rahul Raman, Karthik Viswanathan, Zachary Shriver and Ram Sasisekharan..........429‑435

Published as BJ Immediate Publication 29 May 2012, doi:10.1042/BJ20112101

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 Co-ordination of cell cycle and differentiation in the developing nervous system

Christopher Hindley and Anna Philpott..........375‑382

Published on the Internet 29 May 2012, doi:10.1042/BJ20112040

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 Functional analysis of the protein phosphatase activity of PTEN

Xiaoqun Catherine Zhang, Antonella Piccini, Michael P. Myers, Linda Van Aelst and Nicholas K. Tonks..........457‑464

Published as BJ Immediate Publication 13 March 2012, doi:10.1042/BJ20120098

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 Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase

Charles O. Brown, Kelley Salem, Brett A. Wagner, Soumen Bera, Neeraj Singh, Ajit Tiwari, Amit Choudhury, Garry R. Buettner and Apollina Goel..........515‑527

Published as BJ Immediate Publication 3 April 2012, doi:10.1042/BJ20112019

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 Neuronal caspase 2 activity and function requires RAIDD, but not PIDD

Elena M. Ribe, Ying Y. Jean, Rebecca L. Goldstein, Claudia Manzl, Leonidas Stefanis, Andreas Villunger and Carol M. Troy..........591‑599

Published as BJ Immediate Publication 19 April 2012, doi:10.1042/BJ20111588

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target

Alejandro Giraldo, Oliver P. T. Barrett, Marcus J. Tindall, Stephen J. Fuller, Emre Amirak, Bonhi S. Bhattacharya, Peter H. Sugden and Angela Clerk..........343‑355

Published as BJ Immediate Publication 5 March 2012, doi:10.1042/BJ20120125

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 Renal stem cells: fact or science fiction?

Kristen K. McCampbell and Rebecca A. Wingert..........153‑168

Published on the Internet 11 May 2012, doi:10.1042/BJ20120176

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 Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin

Keefe T. Chan, David W. Roadcap, Nicholas Holoweckyj and James E. Bear..........89‑96

Published as BJ Immediate Publication 27 February 2012, doi:10.1042/BJ20120209

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Volume 443

 Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

Kylie M. Wagstaff, Haran Sivakumaran, Steven M. Heaton, David Harrich and David A. Jans..........851‑856

Published as BJ Immediate Publication 14 March 2012, doi:10.1042/BJ20120150

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 Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation

Xiaoling Wang, Ji Wang, Vera Huang, Robert F. Place and Long‑Cheng Li..........821‑828

Published as BJ Immediate Publication 17 February 2012, doi:10.1042/BJ20111491

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 Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter

Maria A. Whitehead, Michele Bombardieri, Costantino Pitzalis and Bart Vanhaesebroeck..........857‑867

Published as BJ Immediate Publication 29 February 2012, doi:10.1042/BJ20112214

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 An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1

Niall S. Kenneth, J. Michael Younger, Elizabeth D. Hughes, Danielle Marcotte, Philip A. Barker, Thomas L. Saunders and Colin S. Duckett..........355‑359

Published as BJ Immediate Publication 15 February 2012, doi:10.1042/BJ20120249

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online commentary

 A novel lectin from Agrocybe aegerita shows high binding selectivity for terminal N-acetylglucosamine

Shuai Jiang, Yijie Chen, Man Wang, Yalin Yin, Yongfu Pan, Bianli Gu, Guojun Yu, Yamu Li, Barry Hon Cheung Wong, Yi Liang and Hui Sun..........369‑378

Published as BJ Immediate Publication 23 January 2012, doi:10.1042/BJ20112061

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 3′-5′ Phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo

Elie Toledano, Vasily Ogryzko, Antoine Danchin, Daniel Ladant and Undine Mechold..........485‑490

Published as BJ Immediate Publication 12 January 2012, doi:10.1042/BJ20111057

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 Calcium/calmodulin inhibition of the Arabidopsis BRASSINOSTEROID-INSENSITIVE 1 receptor kinase provides a possible link between calcium and brassinosteroid signalling

Man‑Ho Oh, Hyoung Seok Kim, Xia Wu, Steven D. Clouse, Raymond E. Zielinski and Steven C. Huber..........515‑523

Published as BJ Immediate Publication 7 February 2012, doi:10.1042/BJ20111871

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Novel structural arrangement of nematode cystathionine β-synthases: characterization of Caenorhabditis elegans CBS-1

Roman Vozdek, Aleš Hnízda, Jakub Krijt, Marta Kostrouchová and Viktor Kožich..........535‑547

Published as BJ Immediate Publication 13 January 2012, doi:10.1042/BJ20111478

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 Structure–function studies of a plant tyrosyl-DNA phosphodiesterase provide novel insights into DNA repair mechanisms of Arabidopsis thaliana

Hoyeun Kim, Sang Hyeon Na, So‑Young Lee, Young‑Min Jeong, Hyun‑Ju Hwang, Jae Young Hur, Sang‑Hyun Park, Je‑Chang Woo and Sang‑Gu Kim..........49‑56

Published as BJ Immediate Publication 3 January 2012, doi:10.1042/BJ20111308

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 A proximal pair of positive charges provides the dominant ligand-binding contribution to complement-like domains from the LRP (low-density lipoprotein receptor-related protein)

Peter G. W. Gettins and Klavs Dolmer..........65‑73

Published as BJ Immediate Publication 20 December 2011, doi:10.1042/BJ20111867

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 Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase

Katrin Watschinger, Julian E. Fuchs, Vladimir Yarov‑Yarovoy, Markus A. Keller, Georg Golderer, Albin Hermetter, Gabriele Werner‑Felmayer, Nicolas Hulo and Ernst R. Werner..........279‑286

Published as BJ Immediate Publication 6 January 2012, doi:10.1042/BJ20111509

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 Mechanism and specificity of the human paracaspase MALT1

Janna Hachmann, Scott J. Snipas, Bram J. van Raam, Erik M. Cancino, Emily J. Houlihan, Marcin Poreba, Paulina Kasperkiewicz, Marcin Drag and Guy S. Salvesen..........287‑295

Published as BJ Immediate Publication 6 February 2012, doi:10.1042/BJ20120035

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 Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

Linda Troeberg, Barbara Mulloy, Peter Ghosh, Meng‑Huee Lee, Gillian Murphy and Hideaki Nagase..........307‑315

Published as BJ Immediate Publication 3 February 2012, doi:10.1042/BJ20112159

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Volume 442

 Cell signalling by reactive lipid species: new concepts and molecular mechanisms

Ashlee Higdon, Anne R. Diers, Joo Yeun Oh, Aimee Landar and Victor M. Darley‑Usmar..........453‑464

Published on the Internet 24 February 2012, doi:10.1042/BJ20111752

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 Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1, Ngn3 and MafA

Ersin Akinci, Anannya Banga, Lucas V. Greder, James R. Dutton and Jonathan M. W. Slack..........539‑550

Published as BJ Immediate Publication 9 December 2011, doi:10.1042/BJ20111678

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 A molten globule-to-ordered structure transition of Drosophila melanogaster crammer is required for its ability to inhibit cathepsin

Tien‑Sheng Tseng, Chao‑Sheng Cheng, Dian‑Jiun Chen, Min‑Fang Shih, Yu‑Nan Liu, Shang‑Te Danny Hsu and Ping‑Chiang Lyu..........563‑572

Published as BJ Immediate Publication 9 December 2011, doi:10.1042/BJ20111360

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3)

Stephen J. Fuller, Liam J. McGuffin, Andrew K. Marshall, Alejandro Giraldo, Sampsa Pikkarainen, Angela Clerk and Peter H. Sugden..........595‑610

Published as BJ Immediate Publication 9 January 2012, doi:10.1042/BJ20112000

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response

Craig McKibbin, Alina Mares, Michela Piacenti, Helen Williams, Peristera Roboti, Marjo Puumalainen, Anna C. Callan, Karolina Lesiak‑Mieczkowska, Stig Linder, Hanna Harant, Stephen High, Sabine L. Flitsch, Roger C. Whitehead and Eileithyia Swanton..........639‑648

Published as BJ Immediate Publication 6 December 2011, doi:10.1042/BJ20111220

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

Maria N. Navarro, Linda V. Sinclair, Carmen Feijoo‑Carnero, Rosemary Clarke, Sharon A. Matthews and Doreen A. Cantrell..........649‑659

Published as BJ Immediate Publication 10 January 2012, doi:10.1042/BJ20111700

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase

Sébastien Pyr Dit Ruys, Xuemin Wang, Ewan M. Smith, Gaëtan Herinckx, Nusrat Hussain, Mark H. Rider, Didier Vertommen and Christopher G. Proud..........681‑692

Published as BJ Immediate Publication 4 January 2012, doi:10.1042/BJ20111530

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes

Yu Wu, Nora Steinbergs, Tracy Murray‑Stewart, Laurence J. Marton and Robert A. Casero..........693‑701

Published as BJ Immediate Publication 2 December 2011, doi:10.1042/BJ20111271

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Staphylococcus aureus DinG, a helicase that has evolved into a nuclease

Anne‑Marie McRobbie, Bjoern Meyer, Christophe Rouillon, Biljana Petrovic‑Stojanovska, Huanting Liu and Malcolm F. White..........77‑84

Published as BJ Immediate Publication 14 December 2011, doi:10.1042/BJ20111903

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains

Craig R. Pigott, Halina Mikolajek, Claire E. Moore, Stephen J. Finn, Curtis W. Phippen, Jörn M. Werner and Christopher G. Proud..........105‑118

Published as BJ Immediate Publication 24 November 2011, doi:10.1042/BJ20111536

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

Inma M. Berenjeno, Julie Guillermet‑Guibert, Wayne Pearce, Alexander Gray, Stewart Fleming and Bart Vanhaesebroeck..........151‑159

Published as BJ Immediate Publication 7 December 2011, doi:10.1042/BJ20111741

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

Greg C. Smith, Wee Kiat Ong, Gordon W. Rewcastle, Jackie D. Kendall, Weiping Han and Peter R. Shepherd..........161‑169

Published as BJ Immediate Publication 5 December 2011, doi:10.1042/BJ20111913

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Volume 441

 Stepwise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts in situ

Elizabeth G. Canty‑Laird, Yinhui Lu and Karl E. Kadler..........707‑717

Published as BJ Immediate Publication 3 October 2011, doi:10.1042/BJ20111379

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 The multifunctional poly(A)-binding protein (PABP) 1 is subject to extensive dynamic post-translational modification, which molecular modelling suggests plays an important role in co-ordinating its activities

Matthew Brook, Lora McCracken, James P. Reddington, Zhi‑Liang Lu, Nicholas A. Morrice and Nicola K. Gray..........803‑812

Published as BJ Immediate Publication 18 October 2011, doi:10.1042/BJ20111474

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes

Henry Dube, David Selwood, Sylvanie Malouitre, Michela Capano, Michela I. Simone and Martin Crompton..........901‑907

Published as BJ Immediate Publication 28 October 2011, doi:10.1042/BJ20111301

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

Jisun Lee, Samantha Giordano and Jianhua Zhang..........523‑540

Published on the Internet 21 December 2011, doi:10.1042/BJ20111451

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 ADP-ribose polymers localized on Ctcf–Parp1–Dnmt1 complex prevent methylation of Ctcf target sites

Michele Zampieri, Tiziana Guastafierro, Roberta Calabrese, Fabio Ciccarone, Maria G. Bacalini, Anna Reale, Mariagrazia Perilli, Claudio Passananti and Paola Caiafa..........645‑652

Published as BJ Immediate Publication 11 October 2011, doi:10.1042/BJ20111417

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Translation of a minigene in the 5′ leader sequence of the enterohaemorrhagic Escherichia coli LEE1 transcription unit affects expression of the neighbouring downstream gene

Md. Shahidul Islam, Robert K. Shaw, Gad Frankel, Mark J. Pallen and Stephen J. W. Busby..........247‑253

Published as BJ Immediate Publication 6 October 2011, doi:10.1042/BJ20110912

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Relaxin-like factor (RLF)/insulin-like peptide 3 (INSL3) is secreted from testicular Leydig cells as a monomeric protein comprising three domains B–C–A with full biological activity in boars

Itaru Minagawa, Masafumi Fukuda, Hisako Ishige, Hiroshi Kohriki, Masatoshi Shibata, Enoch Y. Park, Tatsuo Kawarasaki and Tetsuya Kohsaka..........265‑273

Published as BJ Immediate Publication 7 September 2011, doi:10.1042/BJ20111107

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

Paul J. Meakin, Alex J. Harper, D. Lee Hamilton, Jennifer Gallagher, Alison D. McNeilly, Laura A. Burgess, Lobke M. Vaanholt, Kirsten A. Bannon, Judy Latcham, Ishrut Hussain, John R. Speakman, David R. Howlett and Michael L.J. Ashford..........285‑296

Published as BJ Immediate Publication 31 August 2011, doi:10.1042/BJ20110512

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage

Ojia Skaff, David I. Pattison, Philip E. Morgan, Rushad Bachana, Vimal K. Jain, K. Indira Priyadarsini and Michael J. Davies..........305‑316

Published as BJ Immediate Publication 5 September 2011, doi:10.1042/BJ20101762

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 Domain assembly of NAADP-gated two-pore channels

Dev Churamani, Robert Hooper, Eugen Brailoiu and Sandip Patel..........317‑323

Published as BJ Immediate Publication 12 October 2011, doi:10.1042/BJ20111617

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Jacob O. Thastrup, Fatema H. Rafiqi, Alberto C. Vitari, Eulalia Pozo‑Guisado, Maria Deak, Youcef Mehellou and Dario R. Alessi..........325‑337

Published as BJ Immediate Publication 28 October 2011, doi:10.1042/BJ20111879

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

Harald W. Platta, Hilde Abrahamsen, Sigrid B. Thoresen and Harald Stenmark..........399‑406

Published as BJ Immediate Publication 22 September 2011, doi:10.1042/BJ20111424

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 Location and dynamics of an active promoter in Escherichia coli K-12

María‑Antonia Sánchez‑Romero, David J. Lee, Eugenio Sánchez‑Morán and Stephen J. W. Busby..........481‑485

Published as BJ Immediate Publication 21 September 2011, doi:10.1042/BJ20111258

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Volume 440

 Intracellular curvature-generating proteins in cell-to-cell fusion

Jean‑Philippe Richard, Evgenia Leikina, Ralf Langen, William Mike Henne, Margarita Popova, Tamas Balla, Harvey T. McMahon, Michael M. Kozlov and Leonid V. Chernomordik..........185‑193

Published as BJ Immediate Publication 7 September 2011, doi:10.1042/BJ20111243

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance

Tânia R. Cabrito, Miguel C. Teixeira, Ashutosh Singh, Rajendra Prasad and Isabel Sá‑Correia..........195‑202

Published as BJ Immediate Publication 10 August 2011, doi:10.1042/BJ20110876

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 The heterotrimeric G protein subunits Gα_q and Gβ₁ have lysophospholipase D activity

Chieko Aoyama, Hiroyuki Sugimoto, Hiromi Ando, Satoko Yamashita, Yasuhiro Horibata, Sayaka Sugimoto and Motoyasu Satou..........241‑250

Published as BJ Immediate Publication 3 August 2011, doi:10.1042/BJ20110545

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 Fluorescence detection of GDP in real time with the reagentless biosensor rhodamine–ParM

Simone Kunzelmann and Martin R. Webb..........43‑49

Published as BJ Immediate Publication 3 August 2011, doi:10.1042/BJ20110349

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 NFAT promotes carcinoma invasive migration through glypican-6

Gary K. Yiu, Aura Kaunisto, Y. Rebecca Chin and Alex Toker..........157‑166

Published as BJ Immediate Publication 26 August 2011, doi:10.1042/BJ20110530

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Volume 439

 Anion channel sensitivity to cytosolic organic acids implicates a central role for oxaloacetate in integrating ion flux with metabolism in stomatal guard cells

Yizhou Wang and Michael R. Blatt..........161‑170

Published as BJ Immediate Publication 11 July 2011, doi:10.1042/BJ20110845

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 Docking interactions of the JNK scaffold protein WDR62

Ksenya Cohen‑Katsenelson, Tanya Wasserman, Samer Khateb, Alan J. Whitmarsh and Ami Aronheim..........381‑390

Published as BJ Immediate Publication 13 July 2011, doi:10.1042/BJ20110284

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Volume 438

Novel regulation of PLCζ activity via its XY-linker

Michail Nomikos, Khalil Elgmati, Maria Theodoridou, Athena Georgilis, J. Raul Gonzalez‑Garcia, George Nounesis, Karl Swann and F. Anthony Lai..........427‑432

Published as BJ Immediate Publication 18 July 2011, doi:10.1042/BJ20110953

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 A role for heparan sulfate proteoglycans in Plasmodium falciparum sporozoite invasion of anopheline mosquito salivary glands

Jennifer S. Armistead, Iain B.H. Wilson, Toin H. van Kuppevelt and Rhoel R. Dinglasan..........475‑483

Published as BJ Immediate Publication 10 June 2011, doi:10.1042/BJ20110694

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 The role of the protein kinase A pathway in the response to alkaline pH stress in yeast

Carlos Casado, Asier González, Maria Platara, Amparo Ruiz and Joaquín Ariño..........523‑533

Published as BJ Immediate Publication 13 July 2011, doi:10.1042/BJ20110607

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Divergent effect of mammalian PLCζ in generating Ca²⁺ oscillations in somatic cells compared with eggs

Sally V. Phillips, Yuansong Yu, Andreas Rossbach, Michail Nomikos, Vyronia Vassilakopoulou, Evangelia Livaniou, Bevan Cumbes, F. Anthony Lai, Christopher H. George and Karl Swann..........545‑553

Published as BJ Immediate Publication 22 June 2011, doi:10.1042/BJ20101581

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities

Lyn‑Marie Birkholtz, Marni Williams, Jandeli Niemand, Abraham I. Louw, Lo Persson and Olle Heby..........229‑244

Published on the Internet 12 August 2011, doi:10.1042/BJ20110362

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Animation

 Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL

Emmanuele Ambrosi, Stefano Capaldi, Michele Bovi, Gianmaria Saccomani, Massimiliano Perduca and Hugo L. Monaco..........291‑301

Published as BJ Immediate Publication 6 June 2011, doi:10.1042/BJ20110257

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

Stephen Jamieson, Jack U. Flanagan, Sharada Kolekar, Christina Buchanan, Jackie D. Kendall, Woo‑Jeong Lee, Gordon W. Rewcastle, William A. Denny, Ripudaman Singh, James Dickson, Bruce C. Baguley and Peter R. Shepherd..........53‑62

Published as BJ Immediate Publication 14 June 2011, doi:10.1042/BJ20110502

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist

Tsuyoshi Goto, Hiroyuki Nagai, Kahori Egawa, Young‑Il Kim, Sota Kato, Aki Taimatsu, Tomoya Sakamoto, Shogo Ebisu, Takahiro Hohsaka, Hiroh Miyagawa, Shigeru Murakami, Nobuyuki Takahashi and Teruo Kawada..........111‑119

Published as BJ Immediate Publication 24 May 2011, doi:10.1042/BJ20101939

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online commentary

Volume 437

 Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution

Gabrielle Fredman and Charles N. Serhan..........185‑197

Published on the Internet 28 June 2011, doi:10.1042/BJ20110327

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

 Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment

Maria V. Barbolina, Rebecca J. Burkhalter and M. Sharon Stack..........1‑12

Published on the Internet 14 June 2011, doi:10.1042/BJ20110112

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

A biochemical analysis of the constraints of tail-anchored protein biogenesis

Pawel Leznicki, Jim Warwicker and Stephen High..........719‑727

Published as BJ Immediate Publication 5 April 2011, doi:10.1042/BJ20101737

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Volume 436

 Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing

Takayuki Ikeda, Li Sun, Naoki Tsuruoka, Yasuhito Ishigaki, Yasuo Yoshitomi, Yoshino Yoshitake and Hideto Yonekura..........399‑407

Published as BJ Immediate Publication 7 March 2011, doi:10.1042/BJ20101490

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Biochemical correlation of activity of the α-dystroglycan-modifying glycosyltransferase POMGnT1 with mutations in muscle-eye-brain disease

Josef Voglmeir, Sara Kaloo, Nicolas Laurent, Marco M. Meloni, Lisa Bohlmann, Iain B. H. Wilson and Sabine L. Flitsch..........447‑455

Published as BJ Immediate Publication 1 March 2011, doi:10.1042/BJ20101059

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia

Philippe Pasdois, Joanne E. Parker, Elinor J. Griffiths and Andrew P. Halestrap..........493‑505

Published as BJ Immediate Publication 17 March 2011, doi:10.1042/BJ20101957

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

InsP₃ receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences

Gyorgy Lur, Mark W. Sherwood, Etsuko Ebisui, Lee Haynes, Stefan Feske, Robert Sutton, Robert D. Burgoyne, Katsuhiko Mikoshiba, Ole H. Petersen and Alexei V. Tepikin..........231‑239

Published as BJ Immediate Publication 3 March 2011, doi:10.1042/BJ20110083

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data | Multimedia

 Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide

Mohd Akif, Sylva L. Schwager, Colin S. Anthony, Bertrand Czarny, Fabrice Beau, Vincent Dive, Edward D. Sturrock and K. Ravi Acharya..........53‑59

Published as BJ Immediate Publication 25 February 2011, doi:10.1042/BJ20102123

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Function of the CysD domain of the gel-forming MUC2 mucin

Daniel Ambort, Sjoerd van der Post, Malin E. V. Johansson, Jenny MacKenzie, Elisabeth Thomsson, Ute Krengel and Gunnar C. Hansson..........61‑70

Published as BJ Immediate Publication 22 February 2011, doi:10.1042/BJ20102066

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Volume 435

Inter- and intra-molecular interactions of Arabidopsis thaliana DELLA protein RGL1

David J. Sheerin, Jeremy Buchanan, Chris Kirk, Dawn Harvey, Xiaolin Sun, Julian Spagnuolo, Sheng Li, Tong Liu, Virgil A. Woods, Toshi Foster, William T. Jones and Jasna Rakonjac..........629‑639

Published as BJ Immediate Publication 15 February 2011, doi:10.1042/BJ20101941

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Recombinant Deg/HtrA proteases from Synechocystis sp. PCC 6803 differ in substrate specificity, biochemical characteristics and mechanism

Pitter F. Huesgen, Helder Miranda, XuanTam Lam, Manuela Perthold, Holger Schuhmann, Iwona Adamska and Christiane Funk..........733‑742

Published as BJ Immediate Publication 21 February 2011, doi:10.1042/BJ20102131

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

 Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130^Cas

Caroline Pellet‑Many, Paul Frankel, Ian M. Evans, Birger Herzog, Manfred Jünemann‑Ramírez and Ian C. Zachary..........609‑618

Published as BJ Immediate Publication 9 February 2011, doi:10.1042/BJ20100580

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Assessing mitochondrial dysfunction in cells

Martin D. Brand and David G. Nicholls..........297‑312

Published on the Internet 29 March 2011, doi:10.1042/BJ20110162

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line

Sarah J. Goodfellow, Michelle R. Rebello, Eneda Toska, Leo A. H. Zeef, Sean G. Rudd, Kathryn F. Medler and Stefan G. E. Roberts..........113‑125

Published as BJ Immediate Publication 26 January 2011, doi:10.1042/BJ20101734

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

A new principle of oligomerization of plant DEG7 protease based on interactions of degenerated protease domains

Holger Schuhmann, Ulrike Mogg and Iwona Adamska..........167‑174

Published as BJ Immediate Publication 19 January 2011, doi:10.1042/BJ20101613

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

How the biotin–streptavidin interaction was made even stronger: investigation via crystallography and a chimaeric tetramer

Claire E. Chivers, Apurba L. Koner, Edward D. Lowe and Mark Howarth..........55‑63

Published as BJ Immediate Publication 18 January 2011, doi:10.1042/BJ20101593

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Volume 434

Crystal structure of unliganded TRAP: implications for dynamic allostery

Ali D. Malay, Masahiro Watanabe, Jonathan G. Heddle and Jeremy R. H. Tame..........427‑434

Published as BJ Immediate Publication 21 December 2010, doi:10.1042/BJ20101813

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4

Linn G. Bjørnstad, Giorgio Zoppellaro, Ane B. Tomter, Pål Ø. Falnes and K. Kristoffer Andersson..........391‑398

Published as BJ Immediate Publication 20 December 2010, doi:10.1042/BJ20101667

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Regulation of cellular iron metabolism

Jian Wang and Kostas Pantopoulos..........365‑381

Published on the Internet 24 February 2011, doi:10.1042/BJ20101825

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | 3D Structure

Male infertility-linked point mutation disrupts the Ca²⁺ oscillation-inducing and PIP₂ hydrolysis activity of sperm PLCζ

Michail Nomikos, Khalil Elgmati, Maria Theodoridou, Brian L. Calver, Bevan Cumbes, Georg Nounesis, Karl Swann and F. Anthony Lai..........211‑217

Published as BJ Immediate Publication 5 January 2011, doi:10.1042/BJ20101772

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice

Angela Woods, Amanda J. Heslegrave, Phillip J. Muckett, Adam P. Levene, Melanie Clements, Margaret Mobberley, Timothy A. Ryder, Shadi Abu‑Hayyeh, Catherine Williamson, Robert D. Goldin, Alan Ashworth, Dominic J. Withers and David Carling..........49‑60

Published as BJ Immediate Publication 30 November 2010, doi:10.1042/BJ20101721

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Volume 433

ERK/p90^RSK/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa

Kumara Dissanayake, Rachel Toth, Jamie Blakey, Olof Olsson, David G. Campbell, Alan R. Prescott and Carol MacKintosh..........515‑525

Published as BJ Immediate Publication 18 November 2010, doi:10.1042/BJ20101562

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Volume 432

Translocation of the Na⁺/H⁺ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling

Scott P. Lawrence, Geoffrey D. Holman and Françoise Koumanov..........515‑523

Published as BJ Immediate Publication 24 September 2010, doi:10.1042/BJ20100717

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development

Yumi Watanabe, Kosei Takeuchi, Susumu Higa Onaga, Michiko Sato, Mika Tsujita, Manabu Abe, Rie Natsume, Minqi Li, Tatsuya Furuichi, Mika Saeki, Tomomi Izumikawa, Ayumi Hasegawa, Minesuke Yokoyama, Shiro Ikegawa, Kenji Sakimura, Norio Amizuka, Hiroshi Kitagawa and Michihiro Igarashi..........47‑55

Published as BJ Immediate Publication 2 September 2010, doi:10.1042/BJ20100847

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

Sharon A. Matthews, Maria N. Navarro, Linda V. Sinclair, Elizabeth Emslie, Carmen Feijoo‑Carnero and Doreen A. Cantrell..........153‑163

Published as BJ Immediate Publication 7 September 2010, doi:10.1042/BJ20101188

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals

R. Thierbach, G. Drewes, M. Fusser, A. Voigt, D. Kuhlow, U. Blume, T. J. Schulz, C. Reiche, H. Glatt, B. Epe, P. Steinberg and M. Ristow..........165‑172

Published as BJ Immediate Publication 6 September 2010, doi:10.1042/BJ20101116

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Functional domains of yeast hexokinase 2

Rafael Peláez, Pilar Herrero and Fernando Moreno..........181‑190

Published as BJ Immediate Publication 3 September 2010, doi:10.1042/BJ20100663

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

R. J. Bird, G. S. Baillie and S. J. Yarwood..........207‑216

Published as BJ Immediate Publication 6 September 2010, doi:10.1042/BJ20101010

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Prevention of diabetic nephropathy in Ins2^+/−AkitaJ mice by the mitochondria-targeted therapy MitoQ

B. K. Chacko, C. Reily, A. Srivastava, M. S. Johnson, Y. Ye, E. Ulasova, A. Agarwal, K. R. Zinn, M. P. Murphy, B. Kalyanaraman and V. D.‑Usmar..........9‑19

Published as BJ Immediate Publication 8 September 2010, doi:10.1042/BJ20100308

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Human OGA binds substrates in a conserved peptide recognition groove

M. Schimpl, A. W. Schüttelkopf, V. S. Borodkin and D. M. F. van Aalten..........1‑7

Published as BJ Immediate Publication 23 September 2010, doi:10.1042/BJ20101338

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Volume 431

A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA

S. Altamura, F. D'Alessio, B. Selle and M. U. Muckenthaler..........363‑371

Published as BJ Immediate Publication 12 August 2010, doi:10.1042/BJ20100668

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle

K. Vichaiwong, S. Purohit, D. An, T. Toyoda, N. Jessen, M. F. Hirshman and L. J. Goodyear..........311‑320

Published as BJ Immediate Publication 11 August 2010, doi:10.1042/BJ20101100

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein

M. J. Ovens, C. Manoharan, M. C. Wilson, C. M. Murray and A. P. Halestrap..........217‑225

Published as BJ Immediate Publication 9 August 2010, doi:10.1042/BJ20100890

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications

Ngee H. Lim, Masahide Kashiwagi, Robert Visse, Jonathan Jones, Jan J. Enghild, Keith Brew and Hideaki Nagase..........113‑122

Published as BJ Immediate Publication 20 July 2010, doi:10.1042/BJ20100725

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Volume 430

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

C. Blackburn, K. M. Gigstad, P. Hales, K. Garcia, M. Jones, F. J. Bruzzese, C. Barrett, Jane X. Liu, Teresa A. Soucy, Darshan S. Sappal, Nancy Bump, E. J. Olhava, P. Fleming, L. R. Dick, C. Tsu, M. D. Sintchak and J. L. Blank..........461‑476

Published as BJ Immediate Publication 15 July 2010, doi:10.1042/BJ20100383

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Evidence for an interaction between Golli and STIM1 in store-operated calcium entry

C. M. Walsh, M. K. Doherty, A. V. Tepikin and R. D. Burgoyne..........453‑460

Published as BJ Immediate Publication 14 July 2010, doi:10.1042/BJ20100650

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit

Sven Dennerlein, Agata Rozanska, Mateusz Wydro, Zofia M. A. Chrzanowska‑Lightowlers and Robert N. Lightowlers..........551‑558

Published as BJ Immediate Publication 6 July 2010, doi:10.1042/BJ20100757

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

R. J. Nichols, Nicolas Dzamko, N. A. Morrice, D. G. Campbell, M. Deak, A. Ordureau, T. Macartney, Y. Tong, J. Shen, A. R. Prescott and D. R. Alessi..........393‑404

Published as BJ Immediate Publication 19 July 2010, doi:10.1042/BJ20100483

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data | Online commentary

Substrate-specific binding and conformational changes involving Ser³¹³ and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking

Z. Hou, J. Wu, Jun Ye, C. Cherian and L. H. Matherly..........265‑274

Published as BJ Immediate Publication 17 June 2010, doi:10.1042/BJ20100181

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Genomic tagging reveals a random association of endogenous PtdIns5P 4-kinases IIα and IIβ and a partial nuclear localization of the IIα isoform

M. Wang, N. J. Bond, A. J. Letcher, J. P. Richardson, K. S. Lilley, R. F. Irvine and J. H. Clarke..........215‑221

Published as BJ Immediate Publication 23 June 2010, doi:10.1042/BJ20100340

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis

A. Recino, V. Sherwood, A. Flaxman, W. N. Cooper, F. Latif, A. Ward and A. D. Chalmers..........207‑213

Published as BJ Immediate Publication 14 July 2010, doi:10.1042/BJ20100883

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

A. E. Lane, J. T. M. Tan, C. L. Hawkins, A. K. Heather and M. J. Davies..........161‑169

Published as BJ Immediate Publication 9 June 2010, doi:10.1042/BJ20100082

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation

E. T. Chouchani, T. R. Hurd, S. M. Nadtochiy, P. S. Brookes, I. M. Fearnley, K. S. Lilley, R. A. J. Smith and M. P. Murphy..........49‑59

Published as BJ Immediate Publication 10 June 2010, doi:10.1042/BJ20100633

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Calmodulin-dependent nuclear import of HMG-box family nuclear factors: importance of the role of SRY in sex reversal

G. Kaur, A. Delluc‑Clavieres, I. K. H. Poon, J. K. Forwood, D. J. Glover and D. A. Jans..........39‑48

Published as BJ Immediate Publication 9 June 2010, doi:10.1042/BJ20091758

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Volume 429

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

I. M. Evans, A. Bagherzadeh, M. Charles, T. Raynham, C. Ireson, A. Boakes, L. Kelland and I. C. Zachary..........565‑572

Published as BJ Immediate Publication 24 May 2010, doi:10.1042/BJ20100578

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Identification of transcriptional networks responding to pyrroloquinoline quinone dietary supplementation and their influence on thioredoxin expression, and the JAK/STAT and MAPK pathways

E. Tchaparian, L. Marshal, G. Cutler, K. Bauerly, W. Chowanadisai, M. Satre, C. Harris and R. B. Rucker..........515‑526

Published as BJ Immediate Publication 21 May 2010, doi:10.1042/BJ20091649

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP

I. B. Ramos, K. Miranda, D. A. Pace, K. C. Verbist, F.‑Y. Lin, Y. Zhang, E. Oldfield, E. A. Machado, W. De Souza and R. Docampo..........485‑495

Published as BJ Immediate Publication 24 May 2010, doi:10.1042/BJ20091956

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants

J. M. Churko, S. Langlois, X. Pan, Q. Shao and D. W. Laird..........473‑483

Published as BJ Immediate Publication 1 June 2010, doi:10.1042/BJ20100155

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Loss of AMP-activated protein kinase α2 subunit in mouse β-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia

C. Beall, K. Piipari, H. Al‑Qassab, M. A. Smith, N. Parker, D. Carling, B. Viollet, D. J. Withers and M. L. J. Ashford..........323‑333

Published as BJ Immediate Publication 13 May 2010, doi:10.1042/BJ20100231

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Role of conservative mutations in protein multi-property adaptation

D. Rodriguez‑Larrea, R. Perez‑Jimenez, I. Sanchez‑Romero, A. Delgado‑Delgado, J. M. Fernandez and J. M. Sanchez‑Ruiz..........243‑249

Published as BJ Immediate Publication 6 May 2010, doi:10.1042/BJ20100386

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

The reconstituted Escherichia coli MsbA protein displays lipid flippase activity

P. D. W. Eckford and F. J. Sharom..........195‑203

Published as BJ Immediate Publication 22 April 2010, doi:10.1042/BJ20100144

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Volume 428

T-cell receptor early signalling complex activation in response to interferon-α receptor stimulation

C. N. Stevens, A. M. Simeone, S. John, Zamal Ahmed, O. M. Lucherini, C. T. Baldari and J. E. Ladbury..........429‑437

Published as BJ Immediate Publication 13 April 2010, doi:10.1042/BJ20091660

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

SENP1 participates in the dynamic regulation of Elk-1 SUMOylation

J. Witty, E. Aguilar‑Martinez and A. D. Sharrocks..........247‑254

Published as BJ Immediate Publication 25 March 2010, doi:10.1042/BJ20091948

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Volume 427

 Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells

Stephen G. Ball, Christopher Bayley, C. Adrian Shuttleworth and Cay M. Kielty..........29‑40

Published as BJ Immediate Publication 26 January 2010, doi:10.1042/BJ20091512

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes

B. Schrul, K. Kapp, I. Sinning and B. Dobberstein..........523‑534

Published as BJ Immediate Publication 3 March 2010, doi:10.1042/BJ20091005

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data | Commentary

The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation

S. D. Hinton, M. P. Myers, V. R. Roggero, L. A. Allison and N. K. Tonks..........349‑357

Published as BJ Immediate Publication 24 February 2010, doi:10.1042/BJ20091383

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Bioinformatic and experimental survey of 14-3-3-binding sites

C. Johnson, S. Crowther, M. J. Stafford, D. G. Campbell, R. Toth and C. MacKintosh..........69‑78

Published as BJ Immediate Publication 8 February 2010, doi:10.1042/BJ20091834

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Dimer–dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba

C. Jelinska, B. Petrovic‑Stojanovska, W. J. Ingledew and M. F. White..........49‑55

Published as BJ Immediate Publication 18 January 2010, doi:10.1042/BJ20091841

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Volume 426

Thr⁴³⁵ phosphorylation regulates RelA (p65) NF-κB subunit transactivation

J. M. O'Shea and N. D. Perkins..........345‑354

Published as BJ Immediate Publication 15 December 2009, doi:10.1042/BJ20091630

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Oct-4 controls cell-cycle progression of embryonic stem cells

J. Lee, Yeorim Go, I. Kang, Y.‑M. Han and J. Kim..........171‑181

Published as BJ Immediate Publication 7 December 2009, doi:10.1042/BJ20091439

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca²⁺ and AMP

S. Fogarty, S. A. Hawley, K. A. Green, N. Saner, K. J. Mustard and D. G. Hardie..........109‑118

Published as BJ Immediate Publication 4 December 2009, doi:10.1042/BJ20091372

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Volume 425

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10

M. J. Ovens, A. J. Davies, M. C. Wilson, C. M. Murray and A. P. Halestrap..........523‑530

Published as BJ Immediate Publication 20 November 2009, doi:10.1042/BJ20091515

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis

D. Kamei, M. Murakami, Y. Sasaki, Y. Nakatani, M. Majima, Y. Ishikawa, T. Ishii, S. Uematsu, S. Akira, S. Hara and I. Kudo..........361‑371

Published as BJ Immediate Publication 21 October 2009, doi:10.1042/BJ20090045

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Doppel and PrP^C co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells

A. Caputo, D. Sarnataro, V. Campana, M. Costanzo, A. Negro, M. C. Sorgato and C. Zurzolo..........341‑351

Published as BJ Immediate Publication 5 November 2009, doi:10.1042/BJ20091050

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Review

Regulation of mRNA cap methylation

V. H. Cowling..........295‑302

Published on the Internet 23 December 2009, doi:10.1042/BJ20091352

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Chloroplast HCF101 is a scaffold protein for [4Fe-4S] cluster assembly

S. Schwenkert, D. J. A. Netz, J. Frazzon, A. J. Pierik, E. Bill, J. Gross, R. Lill and J. ;Meurer..........207‑214

Published as BJ Immediate Publication 9 October 2009, doi:10.1042/BJ20091290

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry

C. M. Walsh, M. Chvanov, L. P. Haynes, O. H. Petersen, A. V. Tepikin and R. D. Burgoyne..........159‑168

Published as BJ Immediate Publication 20 October 2009, doi:10.1042/BJ20090884

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Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

S. Malouitre, H. Dube, D. Selwood and M. Crompton..........137‑148

Published as BJ Immediate Publication 15 October 2009, doi:10.1042/BJ20090332

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Targeting of inositol 1,4,5-trisphosphate receptor to the endoplasmic reticulum by its first transmembrane domain

E. Pantazaka and C. W. Taylor..........61‑69

Published as BJ Immediate Publication 21 October 2009, doi:10.1042/BJ20091051

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Volume 424

Nucleic-acid-binding properties of the C2-L1Tc nucleic acid chaperone encoded by L1Tc retrotransposon

S. R. Heras, M. C. Thomas, F. Macias, M. E. Patarroyo, C. Alonso and M. C. López..........479‑490

Published as BJ Immediate Publication 14 September 2009, doi:10.1042/BJ20090766

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

A putrescine–anthracene conjugate: a paradigm for selective drug delivery

A. J. Palmer, R. A. Ghani, N. Kaur, O. Phanstiel and H. M. Wallace..........431‑438

Published as BJ Immediate Publication 8 October 2009, doi:10.1042/BJ20090815

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A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis

J. Walters, C. Pop, F. L. Scott, M. Drag, P. Swartz, C. Mattos, G. S. Salvesen and A. C. Clark..........335‑345

Published as BJ Immediate Publication 30 September 2009, doi:10.1042/BJ20090825

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data | Multimedia

Review

Calling International Rescue: knowledge lost in literature and data landslide!

T. K. Attwood, D. B. Kell, P. McDermott, J. Marsh, S. ;R. Pettifer and D. Thorne..........317‑333

Published on the Internet 10 December 2009, doi:10.1042/BJ20091474

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Volume 423

Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex

M. Banach‑Orlowska, I. Pilecka, A. Torun, B. Pyrzynska and M. Miaczynska..........389‑400

Published as BJ Immediate Publication 17 August 2009, doi:10.1042/BJ20090086

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells

B. Lener, R. Kozieł, H. Pircher, E. Hütter, R. Greussing, D. Herndler‑Brandstetter, Martin Hermann, Hermann Unterluggauer and Pidder Jansen‑Dürr..........363‑374

Published as BJ Immediate Publication 14 August 2009, doi:10.1042/BJ20090666

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

Glucocorticoids can activate the α-ENaC gene promoter independently of SGK1

N. McTavish, J. Getty, A. Burchell and S. M. Wilson..........189‑197

Published as BJ Immediate Publication 21 July 2009, doi:10.1042/BJ20090366

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Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

T. L. Edwards, V. E. Clowes, H. T. H. Tsang, J. W. Connell, C. M. Sanderson, J. P. Luzio and E. Reid..........31‑39

Published as BJ Immediate Publication 6 July 2009, doi:10.1042/BJ20082398

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Review

Role of plant glyoxylate reductases during stress: a hypothesis

W. L. Allan, S. M. Clark, G. J. Hoover and B. J. Shelp..........15‑22

Published on the Internet 14 September 2009, doi:10.1042/BJ20090826

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Volume 422

Two novel phosphatidylinositol-4-phosphate 5-kinase type Iγ splice variants expressed in human cells display distinctive cellular targeting

N. J. Schill and R. A. Anderson..........473‑482

Published as BJ Immediate Publication 23 June 2009, doi:10.1042/BJ20090638

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

Coupling oxidative signals to protein phosphorylation via methionine oxidation in Arabidopsis

S. C. Hardin, C. T. Larue, M.‑H. Oh, V. Jain and S. C. Huber..........305‑312

Published as BJ Immediate Publication 16 June 2009, doi:10.1042/BJ20090764

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data | Online commentary

GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation

Y. Chen, Y. Deng, J. Zhang, L. Yang, X. Xie and T. Xu..........229‑235

Published as BJ Immediate Publication 2 July 2009, doi:10.1042/BJ20090624

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist

T. Kirchberger, C. Moreau, G. K. Wagner, R. Fliegert, C. C. Siebrands, M. Nebel, F. Schmid, A. Harneit, F. Odoardi, A. Flügel, B. V. L. Potter and A. H. Guse..........139‑149

Published as BJ Immediate Publication 3 June 2009, doi:10.1042/BJ20082308

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Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P₂

G. R. V. Hammond, G. Schiavo and R. F. Irvine..........23‑35

Published as BJ Immediate Publication 9 June 2009, doi:10.1042/BJ20090428

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Volume 421

Receptor-associated protein (RAP) has two high-affinity binding sites for the low-density lipoprotein receptor-related protein (LRP): consequences for the chaperone functions of RAP

J. K. Jensen, K. Dolmer, C. Schar and P. G. W. Gettins..........273‑282

Published as BJ Immediate Publication 27 April 2009, doi:10.1042/BJ20090175

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF | Online Data

NEMO oligomerization and its ubiquitin-binding properties

F. J. Ivins, M. G. Montgomery, S. J. M. Smith, A. C. Morris‑Davies, I. A. Taylor and K. Rittinger..........243‑251

Published as BJ Immediate Publication 7 May 2009, doi:10.1042/BJ20090427

Abstract | Enhanced Full Text | Legacy HTML | Full text PDF

The carbohydrate-binding domain on galectin-1 is more extensive for a complex glycan than for simple saccharides: implications for galectin–glycan interactions at the cell surface

M. C. Miller, I. V. Nesmelova, D. Platt, A. Klyosov and K. H. Mayo..........211‑221

Published as BJ Immediate Publication 12 May 2009, doi:10.1042/BJ20090265

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Review

Function and regulation of phospholipid signalling in plants

H. W. Xue, X. Chen and Y. Mei..........145‑156

Published on the Internet 26 June 2009, doi:10.1042/BJ20090300

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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

J. M. García‑Martínez, J. Moran, R. G. Clarke, A. ;Gray, S. C. Cosulich, C. M. Chresta and D. R. Alessi..........29‑42

Published as BJ Immediate Publication 29 April 2009, doi:10.1042/BJ20090489

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Group III secreted phospholipase A₂ transgenic mice spontaneously develop inflammation

H. Sato, Y. Taketomi, Y. Isogai, S. Masuda, T. Kobayashi, K. Yamamoto and M. Murakami..........17‑27

Published as BJ Immediate Publication 17 April 2009, doi:10.1042/BJ20082429

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Volume 420

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/γ-secretase activity

S. Riedle, H. Kiefel, D. Gast, S. Bondong, S. Wolterink, P. Gutwein and P. Altevogt..........391‑402

Published as BJ Immediate Publication 5 March 2009, doi:10.1042/BJ20081625

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Review

Anaplastic lymphoma kinase: signalling in development and disease

R. H. Palmer, E. Vernersson, C. Grabbe and B. Hallberg..........345‑361

Published on the Internet 27 May 2009, doi:10.1042/BJ20090387

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GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation

H. C. Dorfmueller, V. S. Borodkin, M. Schimpl and D. M. F. van Aalten..........221‑227

Published as BJ Immediate Publication 10 March 2009, doi:10.1042/BJ20090110

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Two distinct signalling cascades target the NF-κB regulatory factor c-IAP1 for degradation

R. A. Csomos, C. W. Wright, S. Galbán, K. A. Oetjen and C. S. Duckett..........83–91

Published as BJ Immediate Publication 25 February 2009, doi:10.1042/BJ20082140

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In vivo regulatory phosphorylation of the phosphoenolpyruvate carboxylase AtPPC1 in phosphate-starved Arabidopsis thaliana

A. L. Gregory, B. A. Hurley, H. T. Tran, A. J. Valentine, Y.-M. She, V. L. Knowles and W. C. Plaxton..........57–65

Published as BJ Immediate Publication 19 February 2009, doi:10.1042/BJ20082397

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Volume 419

Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor

C.J. Duff, M.J. Scott, I.T. Kirby, S.E. Hutchinson, S.L. Martin and N.M. Hooper..........577–584

Published as BJ Immediate Publication 5 February 2009, doi:10.1042/BJ20082407

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Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain

C.N. Hall, R.G. Keynes and J. Garthwaite..........411–418

Published as BJ Immediate Publication 20 January 2009, doi:10.1042/BJ20082419

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A study of the ultrastructure of Fragile-X-related proteins

L. Sjekloća, P.V. Konarev, J. Eccleston, I.A. Taylor, D.I. Svergun and A. Pastore..........347–357

Published as BJ Immediate Publication 14 January 2009, doi:10.1042/BJ20082197

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The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sites

A. Siarheyeva and F.J. Sharom..........317–328

Published as BJ Immediate Publication 8 January 2009, doi:10.1042/BJ20081364

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The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4

P.J. Plant, J. Correa, N. Goldenberg, J. Bain and J. Batt..........57–63

Published as BJ Immediate Publication 6 January 2009, doi:10.1042/BJ20081866

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Volume 418

Physarum nitric oxide synthases: genomic structures and enzymology of recombinant proteins

S. Messner, S. Leitner, C. Bommassar, G. Golderer, P. Gröbner, E.R. Werner and G. Werner-Felmayer..........691–700

Published as BJ Immediate Publication 1 December 2008, doi:10.1042/BJ20080192

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A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels

S.E. Flowerdew and R.D. Burgoyne..........529–540

Published as BJ Immediate Publication 13 January 2009, doi:10.1042/BJ20081736

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Active site substitutions delineate distinct classes of eubacterial flap endonuclease

L.M. Allen, M.R.G. Hodskinson and J.R. Sayers..........285–292

Published as BJ Immediate Publication 11 November 2008, doi:10.1042/BJ20081637

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Volume 417

hVps15, but not Ca²⁺/CaM, is required for the activity and regulation of hVps34 in mammalian cells

Y. Yan, R.J. Flinn, H. Wu, R.S. Schnur and J.M. Backer..........747–755

Published as BJ Immediate Publication 28 October 2008, doi:10.1042/BJ20081865

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Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains

M.B. Protty, N.A. Watkins, D. Colombo, S.G. Thomas, V.L. Heath, J.M.J. Herbert, R. Bicknell, Y.A. Senis, L.K. Ashman, F. Berditchevski, W.H. Ouwehand, S.P. Watson and M.G. Tomlinson..........391–400

Published as BJ Immediate Publication 16 September 2008, doi:10.1042/BJ20081126

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Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective α_1b-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers

M. Canals, J.F. Lopez-Gimenez and G. Milligan..........161–172

Published as BJ Immediate Publication 3 September 2008, doi:10.1042/BJ20081227

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The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors

C. Desjobert, P. Noy, T. Swingler, H. Williams, K. Gaston and P.-S. Jayaraman..........121–132

Published as BJ Immediate Publication 19 August 2008, doi:10.1042/BJ20080872

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Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

R.D. Finn, C.J. Henderson, C.L. Scott and C.R. Wolf..........43–54

Published as BJ Immediate Publication 9 September 2008, doi:10.1042/BJ20080740

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Review

How mitochondria produce reactive oxygen species

M.P. Murphy..........1–13

Published on the Internet 12 December 2008, doi:10.1042/BJ20081386

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Volume 416

Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin

S. Cronier, N. Gros, M.H. Tattum, G.S. Jackson, A.R. Clarke, J. Collinge and J.D.F. Wadsworth..........297–305

Published as BJ Immediate Publication 6 August 2008, doi:10.1042/BJ20081235

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Do mammals make all their own inositol hexakisphosphate?

A.J. Letcher, M.J. Schell and R.F. Irvine..........263–270

Published as BJ Immediate Publication 6 August 2008, doi:10.1042/BJ20081417

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ERα suppresses slug expression directly by transcriptional repression

Y. Ye, Y. Xiao, W. Wang, K. Yearsley, J.-X. Gao and S.H. Barsky..........179–187

Published as BJ Immediate Publication 30 June 2008, doi:10.1042/BJ20080328

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Role of the domain encompassing Arg³⁰⁴–Ile³²⁸ in rat P2X₂ receptor conformation revealed by alterations in complex glycosylation at Asn²⁹⁸

M.T. Young, Y.-H. Zhang, L. Cao, H. Broomhead and L.-H. Jiang..........137–143

Published as BJ Immediate Publication 10 July 2008, doi:10.1042/BJ20081182

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Volume 415

An amino acid at position 142 in nitrilase from Rhodococcus rhodochrous ATCC 33 278 determines the substrate specificity for aliphatic and aromatic nitriles

S.-J. Yeom, H.-J. Kim, J.-K. Lee, D.-E. Kim and D.-K. Oh..........401–407

Published as BJ Immediate Publication 15 April 2008, doi:10.1042/BJ20080440

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Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells

M.A. Amin, S. Matsunaga, S. Uchiyama and K. Fukui..........345–351

Published as BJ Immediate Publication 27 August 2008, doi:10.1042/BJ20081411

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Review

Conformational changes and flexibility in T-cell receptor recognition of peptide–MHC complexes

K.M. Armstrong, K.H. Piepenbrink and B.M. Baker..........183–196

Published on the Internet 25 September 2008, doi:10.1042/BJ20080850

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Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases

F. Gibellini, W.N. Hunter and T.K. Smith..........135–144

Published as BJ Immediate Publication 20 May 2008, doi:10.1042/BJ20080435

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Volume 414

The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network

R.A. Spooner, P. Watson, D.C. Smith, F. Boal, M. Amessou, L. Johannes, G.J. Clarkson, J.M. Lord, D.J. Stephens and L.M. Roberts..........471–484

Published as BJ Immediate Publication 4 June 2008, doi:10.1042/BJ20080149

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Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases

M.S. Alphey, J. König and A.H. Fairlamb..........375–381

Published as BJ Immediate Publication 4 June 2008, doi:10.1042/BJ20080889

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Arf family GTP loading is activated by, and generates, positive membrane curvature

R. Lundmark, G.J. Doherty, Y. Vallis, B.J. Peter and H.T. McMahon..........189–194

Published as BJ Immediate Publication 3 July 2008, doi:10.1042/BJ20081237

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Volume 413

Increasing the expression of calcium-permeable TRPC3 and TRPC7 channels enhances constitutive secretion

V. Lavender, S. Chong, K. Ralphs, A.J. Wolstenholme and B.J. Reaves..........437–446

Published as BJ Immediate Publication 2 May 2008, doi:10.1042/BJ20071488

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High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation

V. Azzu, N. Parker and M.D. Brand..........323–332

Published as BJ Immediate Publication 22 April 2008; doi:10.1042/BJ20080321

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Chaperone ligand-discrimination by the TPR-domain protein Tah1

Stefan H. Millson, Cara K. Vaughan, Chao Zhai, Maruf M. U. Ali, Barry Panaretou, Peter W. Piper, Laurence H. Pearl and Chrisostomos Prodromou..........261‑268

Published as BJ Immediate Publication 15 April 2008, doi:10.1042/BJ20080105

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Specific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cells

N. Venn, L.P. Haynes and R.D. Burgoyne..........71–80

Published as BJ Immediate Publication 7 April 2008, doi:10.1042/BJ20080441

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Volume 412

Regulation of hypoxia-inducible factor-1α by NF-κB

P. van Uden, N.S. Kenneth and S. Rocha..........477–484

Published as BJ Immediate Publication 4 April 2008, doi:10.1042/BJ20080476

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Review

PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate

A. Soufi and P.-S. Jayaraman..........399–413

Published on the Internet 28 May 2008, doi:10.1042/BJ20080035

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Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter

M. Ekerot, M.P. Stavridis, L. Delavaine, M.P. Mitchell, C. Staples, D.M. Owens, I.D. Keenan, R.J. Dickinson, K.G. Storey and S.M. Keyse..........287–298

Published as BJ Immediate Publication 6 March 2008, doi:10.1042/BJ20071512

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CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2–DOP receptor heterodimer

G. Parenty, S. Appelbe and G. Milligan..........245–256

Published as BJ Immediate Publication 29 February 2008, doi:10.1042/BJ20071689

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Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria

N. Parker, C. Affourtit, A. Vidal-Puig and M.D. Brand..........131–139

Published as BJ Immediate Publication 6 February 2008, doi:10.1042/BJ20080006

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Volume 404

Review

Stem cells in the adult pancreas and liver

Z.D. Burke, S. Thowfeequ, M. Peran and D. Tosh..........169–178

Published on the Internet 14 May 2007, doi:10.1042/BJ20070167

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