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Welcome to BJ Metabolism

Discover what's new and interesting in metabolic processes and their regulation from the cellular to the organismal level

In this commentary, Nicolas Venteclef and Pascal Ferré comment on the latest paper by Yajun Duan, Jihong Han and colleagues, who have identified IFN-γ (interferon-γ) as a novel molecular target of LXR (liver X receptor) activation, thereby suggesting a new mechanism by which LXR inhibits tumour growth.
In this open access paper, Alan Fairlamb and colleagues show how N-myristoyltransferase is essential for growth of Trypanosoma cruzi, the parasite that is responsible for Chagas' disease. In addition to performing a detailed biochemical and genetic characterization of the enzyme, evidence is also provided to show that growth is specifically inhibited by blocking N-myristoylation in the parasite.
In this paper, Kazuhisa Sekimizu and colleagues have identified NPC2 (Niemann-Pick disease type C2 protein) as a triglyceride-accumulating factor in insect fluid. Their findings suggest that NPC2 induces triglyceride accumulation via the activation of AMPK (AMP-activated protein kinase) independently of its cholesterol-binding capacity in the silkworm. Listen to Tatsuo Adachi, first author on the paper, discussing this research in his podcast.
In this paper, Andrew Dancis and colleagues show how the Fe-S cluster assembly scaffold protein Isu1 bearing an amino acid change of M107I is able to bypass lack of the frataxin by stimulating cysteine desulfurase activity in mitochondria, even though a kinetic defect in Fe-S cluster assembly persists.
Content in BJ Metabolism
2014 - Volumes 457-464
  • Volume 459
    • part 3, 427-576 (1 May)
    • part 2, 241-425 (15 Apr)
    • part 1, 1-239 (1 Apr)
  • Volume 458
    • part 3, 421-583 (15 Mar)
    • part 2, 187-419 (1 Mar)
    • part 1, 1-185 (15 Feb)
2013 - Volumes 449-456
  • Volume 455
    • part 3, 261-375 (1 Nov)
    • part 2, 133-260 (15 Oct)
    • part 1, 1-131 (1 Oct)
  • Volume 454
    • part 3, 361-595 (15 Sep)
    • part 2, 169-359 (1 Sep)
    • part 1, 1-167 (15 Aug)
  • Volume 453
    • part 3, 311-485 (1 Aug)
    • part 2, 155-310 (15 Jul)
    • part 1, 1-154 (1 Jul)
  • Volume 452
    • part 3, 369-594 (15 Jun)
    • part 2, 173-368 (1 Jun)
    • part 1, 1-171 (15 May)
  • Volume 451
    • part 3, 345-474 (1 May)
    • part 2, 135-343 (15 Apr)
    • part 1, 1-134 (1 Apr)
2012 - Volumes 441-448
  • Volume 448
    • part 3, 297-423 (15 Dec)
    • part 2, 171-295 (1 Dec)
    • part 1, 1-169 (15 Nov)
  • Volume 446
    • part 3, 333-521 (15 Sep)
    • part 2, 165-331 (1 Sep)
    • part 1, 1-163 (15 Aug)
  • Volume 442
    • part 3, 453-742 (15 Mar)
    • part 2, 241-451 (1 Mar)
    • part 1, 1-239 (15 Feb)
2011 - Volumes 433-440
  • Volume 433
    • part 3, 403-535 (1 Feb)
    • part 2, 253-402 (15 Jan)
    • part 1, 1-252 (1 Jan)
2010 - Volumes 425-432
2009 - Volumes 417-424
  • Volume 422
    • part 3, 393-570 (15 Sep)
    • part 2, 193-392 (1 Sep)
    • part 1, 1-191 (15 Aug)
  • Volume 421
    • part 3, 323-483 (1 Aug)
    • part 2, 145-322 (15 Jul)
    • part 1, 1-143 (1 Jul)
  • Volume 420
    • part 3, 345-493 (15 Jun)
    • part 2, 133-343 (1 Jun)
    • part 1, 1-132 (15 May)
  • Volume 419
    • part 3, 519-688 (1 May)
    • part 2, 247-517 (15 Apr)
    • part 1, 1-245 (1 Apr)
  • Volume 418
    • part 3, 475-717 (15 Mar)
    • part 2, 219-473 (1 Mar)
    • part 1, 1-217 (15 Feb)
  • Volume 417
    • part 3, 621-813 (1 Feb)
    • part 2, 401-620 (15 Jan)
    • part 1, 1-400 (1 Jan)
2008 - Volumes 409-416
2007 - Volumes 401-408
2006 - Volumes 393-400
2005 - Volumes 385-392
2004 - Volumes 377-384
2003 - Volumes 369-376
2002 - Volumes 361-368