MondoA is a basic helix-loop-helix (bHLH)/leucine zipper (ZIP) transcription factor that is expressed predominantly in skeletal muscle, and studies in vitro
have suggested that the Max-like protein X (MondoA:Mlx) heterodimer senses the intracellular energy status and directly targets the promoter region of thioredoxin interacting protein (Txnip), and possibly glycolytic enzymes. In this paper, Lawrence Chan and colleagues show that MondoA-knockout (KO) mice display an enhanced capacity for glycolysis and sprinting, but not for endurance exercise. Read the press release
on this paper that was issued by Baylor College of Medicine News.