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Welcome to BJ Metabolism

Discover what's new and interesting in metabolic processes and their regulation from the cellular to the organismal level

In this Commentary, Eric Fontaine draws attention to the significance of the open access paper published recently by Judy Hirst and colleagues, in which they describe the effects of five pharmacologically relevant biguanides on oxidative phosphorylation in mammalian mitochondria, showing how metformin and related compounds affect the activity of both complex I and ATP synthase.
MondoA is a basic helix-loop-helix (bHLH)/leucine zipper (ZIP) transcription factor that is expressed predominantly in skeletal muscle, and studies in vitro have suggested that the Max-like protein X (MondoA:Mlx) heterodimer senses the intracellular energy status and directly targets the promoter region of thioredoxin interacting protein (Txnip), and possibly glycolytic enzymes. In this paper, Lawrence Chan and colleagues show that MondoA-knockout (KO) mice display an enhanced capacity for glycolysis and sprinting, but not for endurance exercise. Read the press release on this paper that was issued by Baylor College of Medicine News.
In Caenorhabditis elegans, fasting induces the lysosomal compartment to expand; however, the molecular and cellular mechanisms for this stress response remain largely unclear. In this paper, Tao Xu, Zheng-xing Wu and colleagues show that short-term fasting leads to increased accumulation of polar lipids in lysosomes, and the fasting response is co-ordinately regulated by EGL-4, the C. elegans PKG (protein kinase G) orthologue, and nuclear hormone receptor NHR-49. Their results reveal a new mechanism for lysosomal lipid metabolism during the stress response, which may provide new clues for investigations of lysosome function in energy homoeostasis.
SM (squalene mono-oxygenase) catalyses the first oxygenation step in cholesterol synthesis, immediately before the formation of the steroid backbone at lanosterol. SM provides an important control point in the pathway, and is regulated post-translationally by accelerated cholesterol-dependent ubiquitination and proteasomal degradation. In this paper, Andrew Brown and colleagues show that SM is stabilized by unsaturated fatty acids, which blunt its polyubiquitination by the E3 ubiquitin ligase MARCH6.
Content in BJ Metabolism
2015 - Volumes 465-472
  • Volume 465
2014 - Volumes 457-464
  • Volume 464
    • part 3, 293-472 (15 Dec)
    • part 2, 169-291 (1 Dec)
    • part 1, 1-168 (15 Nov)
  • Volume 463
    • part 3, 319-437 (1 Nov)
    • part 2, 167-317 (15 Oct)
    • part 1, 1-165 (1 Oct)
  • Volume 462
    • part 3, 385-603 (15 Sep)
    • part 2, 199-384 (1 Sep)
    • part 1, 1-197 (15 Aug)
  • Volume 461
    • part 3, 349-539 (1 Aug)
    • part 2, 159-347 (15 Jul)
    • part 1, 1-158 (1 Jul)
  • Volume 460
    • part 3, 317-473 (15 Jun)
    • part 2, 141-316 (1 Jun)
    • part 1, 1-139 (15 May)
  • Volume 458
    • part 3, 421-583 (15 Mar)
    • part 2, 187-419 (1 Mar)
    • part 1, 1-185 (15 Feb)
2013 - Volumes 449-456
  • Volume 455
    • part 3, 261-375 (1 Nov)
    • part 2, 133-260 (15 Oct)
    • part 1, 1-131 (1 Oct)
  • Volume 454
    • part 3, 361-595 (15 Sep)
    • part 2, 169-359 (1 Sep)
    • part 1, 1-167 (15 Aug)
  • Volume 453
    • part 3, 311-485 (1 Aug)
    • part 2, 155-310 (15 Jul)
    • part 1, 1-154 (1 Jul)
  • Volume 452
    • part 3, 369-594 (15 Jun)
    • part 2, 173-368 (1 Jun)
    • part 1, 1-171 (15 May)
  • Volume 451
    • part 3, 345-474 (1 May)
    • part 2, 135-343 (15 Apr)
    • part 1, 1-134 (1 Apr)
2012 - Volumes 441-448
  • Volume 448
    • part 3, 297-423 (15 Dec)
    • part 2, 171-295 (1 Dec)
    • part 1, 1-169 (15 Nov)
  • Volume 446
    • part 3, 333-521 (15 Sep)
    • part 2, 165-331 (1 Sep)
    • part 1, 1-163 (15 Aug)
  • Volume 442
    • part 3, 453-742 (15 Mar)
    • part 2, 241-451 (1 Mar)
    • part 1, 1-239 (15 Feb)
2011 - Volumes 433-440
  • Volume 433
    • part 3, 403-535 (1 Feb)
    • part 2, 253-402 (15 Jan)
    • part 1, 1-252 (1 Jan)
2010 - Volumes 425-432
2009 - Volumes 417-424
  • Volume 422
    • part 3, 393-570 (15 Sep)
    • part 2, 193-392 (1 Sep)
    • part 1, 1-191 (15 Aug)
  • Volume 421
    • part 3, 323-483 (1 Aug)
    • part 2, 145-322 (15 Jul)
    • part 1, 1-143 (1 Jul)
  • Volume 420
    • part 3, 345-493 (15 Jun)
    • part 2, 133-343 (1 Jun)
    • part 1, 1-132 (15 May)
  • Volume 419
    • part 3, 519-688 (1 May)
    • part 2, 247-517 (15 Apr)
    • part 1, 1-245 (1 Apr)
  • Volume 418
    • part 3, 475-717 (15 Mar)
    • part 2, 219-473 (1 Mar)
    • part 1, 1-217 (15 Feb)
  • Volume 417
    • part 3, 621-813 (1 Feb)
    • part 2, 401-620 (15 Jan)
    • part 1, 1-400 (1 Jan)
2008 - Volumes 409-416
2007 - Volumes 401-408
2006 - Volumes 393-400
2005 - Volumes 385-392
2004 - Volumes 377-384
2003 - Volumes 369-376
2002 - Volumes 361-368