Asymmetric ABC transporters make up a significant proportion of this important superfamily of integral membrane proteins, with Pdr5 multidrug transporter the founding member of the Pdr subfamily of asymmetric ABC transporters. In their review, John Golin and Suresh V. Ambudkar discuss the observations made with Pdr5 and compare them with findings from clinically important asymmetric ABC transporters, such as CFTR (cystic fibrosis transmembrane conductance regulator), Cdr1 and Tap1/Tap2.
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets because they confer substrate specificity on the ubiquitin system. In this review, Emil Bulatov and Alessio Ciulli provide an account of the assembly and structure of Cullin-RING E3 ubiquitin ligase (CRL) complexes, and outline the current state of the field in terms of available knowledge of small-molecule inhibitors and modulators of CRL activity.
Geeta Datta, Philip A. Kramer, Michelle S. Johnson, Hirotaka Sawada, Lesley E. Smythies, David K. Crossman, Balu Chacko, Scott W. Ballinger, David G. Westbrook, Palgunachari Mayakonda, G. M. Anantharamaiah, Victor M. Darley-Usmar and C. Roger White
This study shows that 4F-mediated differentiation of monocyte-derived macrophages to an anti-inflammatory phenotype is due, in part, to an increase in fatty acid uptake and mitochondrial oxidative metabolism.
Metabolic Pathways Analysis 2015
Organized in partnership with the Portuguese Biochemical Society and the Biochemical Society, the Metabolic Pathway Analysis 2015
will take place 8-12th June 2015
at Bom Jesus, Braga, Portugal.
The meeting has a primary focus on the structural (topological) analysis of metabolic networks, and in particular techniques allied to linear algebra, linear programming and computer modelling applied to different fields such as industrial biotechnology and health sciences.
Understanding and Harnessing Bio-Catalysis for Biofuel
To develop new fuel supplies humankind needs better catalysts for CO2
, water and cellulose 'activation'. Nature provides the ultimate inspiration in the form of metabolism which is catalysed by metalloenzymes built from Earth-abundant elements. This Biochemical Society Focused Meeting
will be a forum where the challenges and solutions to harnessing microbial bio-fuel production are discussed and will take place at the end of June.