In this BJ Signal paper, Thimo Kurz and colleagues report a new mode of NEDD8 conjugation ('NEDDylation') whereby this ubiquitin-like modifier protein is linked to proteins by ubiquitin enzymes in vitro.

In this BJ ChemBio paper, which is freely available to all authors, Martin Crompton and colleagues report the synthesis of a modified mitochondrial-targeted CsA (cyclosporin A) with a much-improved cyclophilin D binding affinity relative to the prototype, and show how it yields better cytoprotection than CsA in an isolated cardiomyocyte model of reperfusion injury.

In this BJ Gene paper, Matthew Brook, Nicola Gray and colleagues show that human PABP1 [poly(A)-binding protein 1] is subject to elaborate post-translational modification, and have identified 14 novel modifications located throughout the functional domains, all but one of which are conserved in mouse.