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Current Issue: Volume 468, Issue 2
Latest Issue Highlights
Disease Review:
This review outlines the various molecular and cellular inflammatory mediators responsible for tumour initiation, progression and development, and discusses the critical role of chronic inflammation in tumorigenesis.
Biomolecules Review:
Catalytically inactive enzymes, also known as pseudoproteases, have an extensive and expanding role in biological processes, including regulation, inhibition and immune modulation. In the light of the growing interest in this emerging field this review focuses on the classification, structure, function and mechanism of inactive enzymes. Examples of how inactivity is defined, how this is reflected in the structure, functions of inactive enzymes in biological processes and their mode of action are discussed.
Biomolecules Research:
This X-ray crystal structure of the ectodomain of delta-like ligand-1 (Dll-1) represents the largest fragment of any Notch ligand structure to date. Comparison with the Jagged1 structures reveals similarities and differences between the ligand families and potential receptor binding sites.
Energy Research:
ATP, the fuel of life, is produced in mitochondria of living cells by a molecular machine, the ATP synthase. We have isolated the machines from four fungal species, compared their stabilities and identified the proteins from which they are constructed.
Upcoming meetings
Metabolic Pathways Analysis 2015
Organized in partnership with the Portuguese Biochemical Society and the Biochemical Society, the Metabolic Pathway Analysis 2015 will take place 8-12th June 2015 at Bom Jesus, Braga, Portugal.
The meeting has a primary focus on the structural (topological) analysis of metabolic networks, and in particular techniques allied to linear algebra, linear programming and computer modelling applied to different fields such as industrial biotechnology and health sciences.

Understanding and Harnessing Bio-Catalysis for Biofuel
To develop new fuel supplies humankind needs better catalysts for CO2, H2, water and cellulose 'activation'. Nature provides the ultimate inspiration in the form of metabolism which is catalysed by metalloenzymes built from Earth-abundant elements. This Biochemical Society Focused Meeting will be a forum where the challenges and solutions to harnessing microbial bio-fuel production are discussed and will take place at the end of June.