Nishad Matange, Marjetka Podobnik and Sandhya S. Visweswariah
In this review the authors present an overview of metallophosphoesterases, highlighting aspects of their biochemistry, structure and function. Despite the high degree of structural similarity these enzymes are versatile in terms of substrate utilization, and in many cases, their precise biological roles remain enigmatic.
Yosua Adi Kristariyanto, Soo Youn Choi, Syed Arif Abdul Rehman, Maria Stella Ritorto, David G Campbell, Nicholas A Morrice, Rachel Toth and Yogesh Kulathu
Of the eight different polyubiquitin linkage types, very little is known about Lys33-linked polyubiquitin. Here the authors reveal that the HECT E3 ligase AREL1 assembles Lys33-linked polyubiquitin, and establish a method for large-scale assembly that enabled structural and biochemical studies.
Joanna D. Stewart, Joanne L. Cowan, Lisa S. Perry, Mark J. Coldwell and Christopher G. Proud
This study shows that ATP-binding cassette protein 50, which binds eukaryotic initiation factor-2, plays a key role in translation initiation. ATPase-defective mutants of ABC50 usurp the accuracy of the recognition of start codons, suggesting it helps ensure the accuracy of initiation.
Brian H. Shilton
Active membrane transporters are dynamic molecular machines that catalyse transport across a membrane by coupling solute movement to a source of energy such as ATP or a secondary ion gradient. A central question for many active transporters concerns the mechanism by which transport is coupled to a source of energy. The present review discusses active transport using the well-established energetic framework for enzyme-mediated catalysis. In particular, membrane transport systems can be viewed as ensembles consisting of low-energy and high-energy conformations.
A Biochemical Society Focused Meeting - ABC Transporters: from mechanism to organism
ABC transporters are one of the largest families of membrane proteins and their diverse functions underpin numerous key physiological processes, as well as being causative factors in a number of clinically relevant pathologies. This meeting will focus on the mechanisms of ABC transporters and how this is integral to their effects on organism and cell biology.
For more information, see here
Metabolic Pathways Analysis 2015
Organized in partnership with the Portuguese Biochemical Society and the Biochemical Society, the Metabolic Pathway Analysis 2015
will take place 8-12th June 2015
at Bom Jesus, Braga, Portugal.
The meeting has a primary focus on the structural (topological) analysis of metabolic networks, and in particular techniques allied to linear algebra, linear programming and computer modelling applied to different fields such as industrial biotechnology and health sciences.