Download to Citation Manager

Biochem. J. (2011) doi:10.1042/BJ20111603

Enhanced Full Text

Full Text PDF

Original 1966 article by Hems et al.

Original 1972 article by Hems et al.

Download semantic tools

Citing articles

Article usage metrics

Classic paper

From gluconeogenesis to hepatic physiology: the dream team meets liver perfusion

John T. Brosnan¹ and Margaret E. Brosnan

Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL, Canada A1B 3X9

This Biochemical Journal ‘Classic paper’ article describes the development in the Krebs laboratory of a simple and robust procedure for perfusion of the rat liver. Although initially designed for the study of gluconeogenesis, the procedure has been widely used for a variety of studies which require a physiological in vitro liver preparation.

Key words: gluconeogenesis, isolated hepatocytes, Hans Krebs, liver slices, ureagenesis.

¹To whom correspondence should be addressed (email jbrosnan@mun.ca).

Published online 22 December 2011, doi:10.1042/BJ20111603

© The Authors Journal compilation © 2012 Biochemical Society