Biochem. J. (2007) doi:10.1042/BJ2007c003
Classic paper
Inhibiting the uninhibited: on the specificity of protein kinase inhibitors
Alex TOKER
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, U.S.A.
Use of protein kinase inhibitors is ubiquitous, but until Philip Cohen and colleagues combined old-fashioned biochemistry with modern high-throughput screening technology, the specificity of many commercially available inhibitors had not been rigorously tested even within the same kinase family. This Classics article looks at how protein kinase inhibitors should now be evaluated against certain benchmarks that address both specificity and efficacy.
© The Authors Journal compilation © 2007 Biochemical Society
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