Most read Reviews

Which papers published in the last 3 years are being downloaded the most?
The number of downloads in the 12 months to the end of April 2013 are shown below

6972	Autophagy, mitochondria and oxidative stress: cross talk and redox signaling Jisun Lee, Samantha Giordano and Jianhua Zhang (2012) 441, 523-540 doi:10.1042/BJ20111451 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
5330	Regulation of cellular iron metabolism Jian Wang and Kostas Pantopoulos (2011) 434, 365-381 doi:10.1042/BJ20101825 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
4366	Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks Brian Magnuson, Bilgen Ekim and Diane Fingar (2012) 441, 1-21 doi:10.1042/BJ20110892 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
4288	Lentiviral vectors: basic to translational Toshie Sakuma, Michael Barry and Yasuhiro Ikeda (2012) 443, 603-618 doi:10.1042/BJ20120146 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3643	AMP-activated protein kinase: new regulation, new roles? David Carling, Claire Thornton, Angela Woods and Matthew Sanders (2012) 445, 11-27 doi:10.1042/BJ20120546 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3521	Regulation and function of the RSK family of protein kinases Yves Romeo, Xiaocui Zhang and Philippe Roux (2012) 441, 553-569 doi:10.1042/BJ20110289 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3316	SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and ageing Albert Giralt and Francesc Villarroya (2012) 444, 1-10 doi:10.1042/BJ20120030 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3290	Fibroblast Growth Factors and their Receptors in Cancer Jørgen Wesche, Kaisa Haglund and Ellen Haugsten (2011) 437, 199-213 doi:10.1042/BJ20101603 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3058	Signal transduction by vascular endothelial growth factor receptors Sina Koch, Sònia Tugues, Xiujuan Li, Laura Gualandi and Lena Claesson-Welsh (2011) 437, 169-183 doi:10.1042/BJ20110301 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3039	Replication fork dynamics and the DNA damage response Rebecca Jones and Eva Petermann (2012) 443, 13-26 doi:10.1042/BJ20112100 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2963	Regulation of spermiogenesis, spermiation and blood-testis barrier dynamics: novel insights from studies on Eps8 and Arp3 C. Yan Cheng and Dolores Mruk (2011) 435, 553-562 doi:10.1042/BJ20102121 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2721	Assessing mitochondrial dysfunction in cells Martin Brand and David Nicholls (2011) 435, 297-312 doi:10.1042/BJ20110162 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2389	Vitamin D and cancer: a review of molecular mechanisms James Fleet, Marsha DeSmet, Robert Johnson and Yan Li (2012) 441, 61-76 doi:10.1042/BJ20110744 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2378	Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration Antje Schaefer, Micha Nethe and Peter Hordijk (2012) 442, 13-25 doi:10.1042/BJ20111815 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2265	Role and function of macrophages in the metabolic syndrome Chih-Hao Lee and Prerna Bhargava (2012) 442, 253-262 doi:10.1042/BJ20111708 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2202	Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signaling and therapeutic targeting Min Ni, Yi Zhang and Amy Lee (2011) 434, 181-188 doi:10.1042/BJ20101569 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2113	The Proteomic Future: Where Mass Spectrometry Should Be Taking Us Jay Thelen and Jan Miernyk (2012) 444, 169-181 doi:10.1042/BJ20110363 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2098	Is the Amyloid Hypothesis of Alzheimer’s disease therapeutically relevant? Andrew Teich and Ottavio Arancio (2012) 446, 165-177 doi:10.1042/BJ20120653 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2065	The Golgi apparatus: an organelle with multiple complex functions Cathal Wilson, Rossella Venditti, Laura Rega, Antonino Colanzi, Giovanni D’Angelo and Maria De Matteis (2011) 433, 1-9 doi:10.1042/BJ20101058 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1902	PI3K Signaling in B and T Lymphocytes: New Developments and Therapeutic Advances Lomon So and David FRUMAN (2012) 442, 465-481 doi:10.1042/BJ20112092 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1862	The post-transcriptional life of mammalian mitochondrial RNA Joanna Rorbach and Michal Minczuk (2012) 444, 357-373 doi:10.1042/BJ20112208 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1849	Glycogen and its metabolism: some new developments and old themes PJ Roach, Anna DePaoli-Roach, Thomas Hurley and Vincent Tagliabracci (2012) 441, 763-787 doi:10.1042/BJ20111416 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1831	Super toxins from a super bug: structure and function of Clostridium difficile toxins Abigail Davies, April Roberts, Clifford Shone and K. Ravi Acharya (2011) 436, 517-526 doi:10.1042/BJ20110106 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1753	Molecular targets of oxidative stress Simon Avery (2011) 434, 201-210 doi:10.1042/BJ20101695 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1740	ATR signaling: more than meeting at the fork Edward Nam and David Cortez (2011) 436, 527-536 doi:10.1042/BJ20102162 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1725	Fulfilling the metabolic requirements for cell proliferation Salvador Moncada, E Higgs and Sergio Colombo (2012) 446, 1-7 doi:10.1042/BJ20120427 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1654	The Hippo Pathway and Apico-Basal Cell Polarity Alice Genevet and Nicolas Tapon (2011) 436, 213-224 doi:10.1042/BJ20110217 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1565	Intestinal Absorption of Water-Soluble Vitamins in Health and Disease Hamid Said (2011) 437, 357-372 doi:10.1042/BJ20110326 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1564	Plant Cell Walls to Ethanol Douglas Jordan, Michael Bowman, Jay Braker, Bruce Dien, Ronald Hector, Charles Lee, Jeffrey Mertens and Kurt Wagschal (2012) 442, 241-252 doi:10.1042/BJ20111922 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1526	Ceramide synthases at the centre of sphingolipid metabolism and biology Thomas Mullen, Yusuf Hannun and Lina Obeid (2012) 441, 789-802 doi:10.1042/BJ20111626 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1510	Gibberellin biosynthesis and its regulation Peter Hedden and Stephen Thomas (2012) 444, 11-25 doi:10.1042/BJ20120245 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1499	Wnt/β-catenin signaling: From plasma membrane to nucleus Wantae Kim, Minseong Kim and Eek-hoon Jho (2013) 450, 9-21 doi:10.1042/BJ20121284 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1491	Tetrahydrobiopterin: biochemistry and pathophysiology Ernst Werner, Nenad Blau and Beat Thony (2011) 438, 397-414 doi:10.1042/BJ20110293 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1478	Regulation of mitochondrial metabolism: Yet another facet in the biology of the onco-protein Bcl-2 Shefali Krishna, Ivan Low and Shazib Pervaiz (2011) 435, 545-551 doi:10.1042/BJ20101996 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1470	The role of amino acid transporters in inherited and acquired diseases Stefan Broer and Manuel Palacín (2011) 436, 193-211 doi:10.1042/BJ20101912 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1464	Co-ordination of cell cycle and differentiation in the developing nervous system Christopher Hindley and Anna Philpott (2012) 444, 375-382 doi:10.1042/BJ20112040 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1463	Renal Stem Cells: Fact or Science Fiction? Kristen McCampbell and Rebecca Wingert (2012) 444, 153-168 doi:10.1042/BJ20120176 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1457	Alternative Affinity Tools - More attractive than Antibodies? Vincent Ruigrok, Mark Levisson, Michel Eppink, Hauke Smidt and John van der Oost (2011) 436, 1-13 doi:10.1042/BJ20101860 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1431	Virology and molecular pathogenesis of HPV (human papillomavirus)-associated oropharyngeal squamous cell carcinoma Daniel Miller, Michael Puricelli and M. Sharon Stack (2012) 443, 339-353 doi:10.1042/BJ20112017 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1426	Cell signalling by reactive lipid species: new concepts and molecular mechanisms Ashlee Higdon, Anne Diers, Joo Yeun Oh, Aimee Landar and Victor Darley-Usmar (2012) 442, 453-464 doi:10.1042/BJ20111752 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1381	The many faces of p38 MAPK in progenitor/stem cell differentiation Feride Oeztuerk-Winder and Juan-Jose Ventura (2012) 445, 1-10 doi:10.1042/BJ20120401 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1352	Antioxidant and bioenergetic coupling between neurons and astrocytes Seila Fernandez-Fernandez, Angeles Almeida and Juan Bolaños (2012) 443, 3-12 doi:10.1042/BJ20111943 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1350	Biochemical role of the collagen-rich tumor microenvironment in pancreatic cancer progression Mario Shields, Surabhi Dangi-Garimella, Amanda Redig and Hidayatullah Munshi (2012) 441, 541-552 doi:10.1042/BJ20111240 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1325	Proteases as Therapeutics Charles Craik, Michael Page and Edwin Madison (2011) 435, 1-16 doi:10.1042/BJ20100965 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1321	MeCP2 and Rett Syndrome – reversibility and potential avenues for therapy Kamal Gadalla, Mark Bailey and Stuart Cobb (2011) 439, 1-14 doi:10.1042/BJ20110648 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1313	Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking Paul Mellor, Levi Furber, Jennifer Nyarko and Deborah Anderson (2012) 441, 23-37 doi:10.1042/BJ20111164 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1310	Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease Rohan Teasdale and Brett Collins (2012) 441, 39-59 doi:10.1042/BJ20111226 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1307	Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signaling Xiaohua Yan and Ye-Guang Chen (2011) 434, 1-10 doi:10.1042/BJ20101827 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1260	Cell polarity during motile processes: keeping on track with the exocyst complex Maud Hertzog and Philippe Chavrier (2011) 433, 403-409 doi:10.1042/BJ20101214 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
1236	How protein kinases coordinate mitosis in animal cells Hoi Tang Ma and Randy Poon (2011) 435, 17-31 doi:10.1042/BJ20100284 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF