Most downloaded papers

12997	Review Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology Sören Beinke and Steven C Ley (2004) 382, 393-409 doi:10.1042/BJ20040544 Abstract | Legacy HTML | Full text PDF
11530	Review Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway P C Heinrich, I Behrmann, G Müller-Newen, F Schaper and L Graeve (1998) 334, 297-314 Abstract | Legacy HTML | Full text PDF
9513	Review Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions W Kolch (2000) 351, 289-305 Abstract | Legacy HTML | Full text PDF
9059	Review Principles of interleukin (IL)-6-type cytokine signalling and its regulation Peter C Heinrich, Iris Behrmann, Serge Haan, Heike M Hermanns, Gerhard Müller-Newen and Fred Schaper (2003) 374, 1-20 doi:10.1042/BJ20030407 Abstract | Legacy HTML | Full text PDF
8932	Review Structure, function and regulation of pyruvate carboxylase S Jitrapakdee and J C Wallace (1999) 340, 1-16 Abstract | Legacy HTML | Full text PDF
8591	A sodium carbonate-bicarbonate buffer for alkaline phosphatases G E Delory (1945) 39, 245-245 Abstract | Full text PDF
8208	Review Novel molecular approaches to cystic fibrosis gene therapy Tim W R Lee, David A Matthews and G Eric Blair (2005) 387, 1-15 doi:10.1042/BJ20041923 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
7497	Review Effects of nitrogen monoxide and carbon monoxide on molecular and cellular iron metabolism: mirror-image effector molecules that target iron Ralph N Watts, Prem Ponka and Des R Richardson (2003) 369, 429-440 doi:10.1042/BJ20021302 Abstract | Legacy HTML | Full text PDF
7136	Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells C Albert, S T Safrany, M E Bembenek, K M Reddy, K Reddy, J Falck, M Bröcker, S B Shears and G W Mayr (1997) 327, 553-560 Abstract | Legacy HTML | Full text PDF
6495	Review Nitric oxide synthases: structure, function and inhibition W K Alderton, C E Cooper and R G Knowles (2001) 357, 593-615 Abstract | Legacy HTML | Full text PDF
6207	Review Mouse behavioural analysis in systems biology Peter Van Meer and Jacob Raber (2005) 389, 593-610 doi:10.1042/BJ20042023 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
5912	Review Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation P J Coffer, J Jin and J R Woodgett (1998) 335, 1-13 Abstract | Legacy HTML | Full text PDF
5838	Review Chaperonins N A Ranson, H E White and H R Saibil (1998) 333, 233-242 Abstract | Legacy HTML | Full text PDF
5606	Ability of a beta-casein phosphopeptide to modulate the precipitation of calcium phosphate by forming amorphous dicalcium phosphate nanoclusters C Holt, N M Wahlgren and T Drakenberg (1996) 314, 1035-1039 Abstract | Legacy HTML | Full text PDF
5541	Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae Daniel Shenton and Chris M Grant (2003) 374, 513-519 doi:10.1042/BJ20030414 Abstract | Legacy HTML | Full text PDF
5361	The selective fermentation of glucose and fructose by yeast E R Dawson (1932) 26, 531-535 Abstract | Full text PDF
5290	Review Rho GTPases and their effector proteins A L Bishop and A Hall (2000) 348, 241-255 Abstract | Legacy HTML | Full text PDF
5194	Review The unique features of glycolytic pathways in Archaea Corné H Verhees, Servé W M Kengen, Judith E Tuininga, Gerrit J Schut, Michael W W Adams, Willem M De Vos and John Van Der Oost (2003) 375, 231-246 doi:10.1042/BJ20021472 Abstract | Legacy HTML | Full text PDF
4806	Glutamine synthesis is heterogeneous and differentially regulated along the rabbit renal proximal tubule B Ferrier, A Conjard, M Martin and G Baverel (1999) 337, 543-550 Abstract | Legacy HTML | Full text PDF
4802	Review Signal transduction by the Wnt family of ligands T C Dale (1998) 329, 209-223 Abstract | Legacy HTML | Full text PDF
4767	Review Sphingosine 1-phosphate signalling in mammalian cells S Pyne and N J Pyne (2000) 349, 385-402 Abstract | Legacy HTML | Full text PDF
4742	Specificity and mechanism of action of some commonly used protein kinase inhibitors S P Davies, H Reddy, M Caivano and P Cohen (2000) 351, 95-105 Abstract | Legacy HTML | Full text PDF
4694	Review Transglutaminases: nature's biological glues Martin Griffin, Rita Casadio and Carlo M Bergamini (2002) 368, 377-396 doi:10.1042/BJ20021234 Abstract | Legacy HTML | Full text PDF
4468	Review Dual-specificity phosphatases: critical regulators with diverse cellular targets Kate I Patterson, Tilman Brummer, Philippa M O'Brien and Roger J Daly (2009) 418, 475-489 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
4300	Review Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors E Hermans and R A Challiss (2001) 359, 465-484 Abstract | Legacy HTML | Full text PDF
4294	Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes Carsten B Andersen, Hiroshi Sakaue, Taku Nedachi, Kristina S Kovacina, Carol Clayberger, Marco Conti and Richard A Roth (2003) 369, 227-238 doi:10.1042/BJ20021243 Abstract | Legacy HTML | Full text PDF
4132	Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide Suwei Wang, Srigiridhar Kotamraju, Eugene Konorev, Shasi Kalivendi, Joy Joseph and Balaraman Kalyanaraman (2002) 367, 729-740 doi:10.1042/BJ20020752 Abstract | Legacy HTML | Full text PDF
4093	Review PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation Zhou-shen Zhao and Ed Manser (2005) 386, 201-214 doi:10.1042/BJ20041638 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
4038	Review Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis Guy A Rutter, Gabriela Da Silva Xavier and Isabelle Leclerc (2003) 375, 1-16 doi:10.1042/BJ20030048 Abstract | Legacy HTML | Full text PDF
4000	Review Connexin 43 phosphorylation - Structural changes and biological effects Joell Solan and Paul Lampe (2009) 419, 261-272 doi:10.1042/BJ20082319 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3994	Review GSK3 takes centre stage more than 20 years after its discovery S Frame and P Cohen (2001) 359, 1-16 Abstract | Legacy HTML | Full text PDF
3922	Review Arginine metabolism: nitric oxide and beyond G Wu and S M Morris (1998) 336, 1-17 Abstract | Legacy HTML | Full text PDF
3881	Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling Li Liu, Takashi Sakai, Nobuya Sano and Kiyoshi Fukui (2004) 380, 31-41 doi:10.1042/BJ20031300 Abstract | Legacy HTML | Full text PDF
3843	Review Retinoid-binding proteins: mediators of retinoid action N Noy (2000) 348, 481-495 Abstract | Legacy HTML | Full text PDF
3802	Review Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling D T Denhardt (1996) 318, 729-747 Abstract | Legacy HTML | Full text PDF
3728	Review Emerging and diverse roles of protein kinase C in immune cell signalling Seng-Lai Tan and Peter J Parker (2003) 376, 545-552 doi:10.1042/BJ20031406 Abstract | Legacy HTML | Full text PDF
3717	Review Biochemistry and pathology of radical-mediated protein oxidation R T Dean, S Fu, R Stocker and M J Davies (1997) 324, 1-18 Abstract | Legacy HTML | Full text PDF
3643	Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels T Chitlaru, C Kronman, M Zeevi, M Kam, A Harel, A Ordentlich, B Velan and A Shafferman (1998) 336, 647-658 Abstract | Legacy HTML | Full text PDF
3639	Review Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes Carol Mackintosh (2004) 381, 329-342 doi:10.1042/BJ20031332 Abstract | Legacy HTML | Full text PDF
3489	Review Pathogen Recognition in the Innate Immune Response Himanshu Kumar, Taro Kawai and Shizuo Akira (2009) 420, 1-16 doi:10.1042/BJ20090272 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3403	Review The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation Lars P Van Der Heide, Marco F M Hoekman and Marten P Smidt (2004) 380, 297-309 doi:10.1042/BJ20040167 Abstract | Legacy HTML | Full text PDF
3395	Review Histone deacetylases (HDACs): characterization of the classical HDAC family Annemieke J M de Ruijter, Albert H van Gennip, Huib N Caron, Stephan Kemp and André B P van Kuilenburg (2003) 370, 737-749 doi:10.1042/BJ20021321 Abstract | Legacy HTML | Full text PDF
3373	High-throughput metabolic state analysis: the missing link in integrated functional genomics of yeasts Silas G Villas-Bôas, Joel F Moxley, Mats Akesson, Gregory Stephanopoulos and Jens Nielsen (2005) 388, 669-677 doi:10.1042/BJ20041162 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3325	Review Regulation of serum amyloid A protein expression during the acute-phase response L E Jensen and A S Whitehead (1998) 334, 489-503 Abstract | Legacy HTML | Full text PDF
3280	Review Getting into position: the catalytic mechanisms of protein ubiquitylation Lori A Passmore and David Barford (2004) 379, 513-525 doi:10.1042/BJ20040198 Abstract | Legacy HTML | Full text PDF
3264	Review Sorting and storage during secretory granule biogenesis: looking backward and looking forward P Arvan and D Castle (1998) 332, 593-610 Abstract | Legacy HTML | Full text PDF
3241	Overexpression of UDP-glucose dehydrogenase in Escherichia coli results in decreased biosynthesis of K5 polysaccharide Elisabet Roman, Ian Roberts, Kerstin Lidholt and Marion Kusche-Gullberg (2003) 374, 767-772 doi:10.1042/BJ20030365 Abstract | Legacy HTML | Full text PDF
3163	Review Signal cooperation between integrins and other receptor systems C Streuli and Nasreen Akhtar (2009) 418, 491-506 doi:10.1042/BJ20081948 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3145	Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway Karnam S Murthy, Huiping Zhou, John R Grider, David L Brautigan, Masumi Eto and Gabriel M Makhlouf (2003) 374, 145-155 doi:10.1042/BJ20021274 Abstract | Legacy HTML | Full text PDF
3124	Review The mitochondrial permeability transition pore and its role in cell death M Crompton (1999) 341, 233-249 Abstract | Legacy HTML | Full text PDF