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Biochem. J. (2007) 405 (199–221) (Printed in Great Britain)

Review article

Structures and metal-ion-binding properties of the Ca2+-binding helix–loop–helix EF-hand motifs

Jessica L. GIFFORD*, Michael P. WALSH† and Hans J. VOGEL*1

*Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4, and †Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1

Figure 3 The co-ordination sphere of the canonical EF loop

Part (C) shows Ca²⁺ co-ordination by the canonical EF hand (EF1 of CaM) illustrating both the pentagonal bipyramidal co-ordination of the Ca²⁺ ion (continuous lines) and the extensive hydrogen bonding pattern found in the loop (broken lines) [10]. The backbone NH groups are indicated in black, the side chain oxygen atoms in red, the Ca²⁺ ion in yellow and the co-ordinating water in blue (PDB code 1EXR) [175].

Received 19 February 2007/24 April 2007; accepted 25 April 2007

Published on the Internet 27 June 2007, doi:10.1042/BJ20070255

© The Authors Journal compilation © 2007 Biochemical Society